FOLFOX4方案治疗晚期结直肠癌的临床观察  

Clinical observation of FOLFOX4 protocol for advanced colorectal cancer

作　　者：吴东平[1] 吕杰青[1] 陶锋[1] 王建芳[1] 王松祥[1] 

机构地区：[1]浙江省绍兴市人民医院肿瘤科,312000

出　　处：《肿瘤研究与临床》2006年第4期255-257,共3页Cancer Research and Clinic

摘　　要：目的评价FOLFOX4方案治疗晚期结直肠癌的临床疗效。方法采用草酸铂(OXA)85mg/m2,静脉滴注2h,第1天;亚叶酸钙(LV)200mg/m2,静脉滴注2h,第1～2天;5-氟尿嘧啶(5-Fu)400mg/m2,第1～2天静脉注射;5-Fu600mg/m2持续静脉滴注(22h)第1～2天的方案治疗27例晚期结直肠癌。2周为1周期,重复4周期后间隔1个月评定疗效。结果全组27例,CR1例(3.70%),PR11例(40.74%),总有效率(44.44%)。中位生存期10.0个月,平均生存期11.5个月,1年生存率30.02%。12例治疗有效病例中位缓解期为5.3个月。治疗有效(CR+PR)病例、治疗无效病例的中位生存期分别为11.8,8.5个月。治疗有效病例的中位生存期显著好于无效病例(P<0.05)。Ⅲ,Ⅳ度神经毒性发生率为14.81%,腹泻、黏膜炎及血液学毒性不影响治疗。结论FOLFOX4方案治疗晚期结直肠癌有效安全,可作为晚期结直肠癌首选化疗方案。Objective To evaluate the efficacy and toxicity of the protocol of FOLFOX4 for advanced colorectal cancer. Methods 27 patients received FOLFOX4[oxaliplatin 85 mg/m^2 as a 2-hour infusion on day 1 and a 2-hour infusion of LV （200 mg· m^-2· d^-1） followed by a 5-Fu bolus （400 mg· m^-2· d^-1） and 22-hour infusion （600 mg· m^-2· d^-1） for 2 consecutive days every 2 weeks]. Four courses were carried out with an interval of one month. Results The total effective rate was 44.44 %, CR（3.70 %）, PR（40.74 %）. Median survival of all patients was 10.0 months. Mean Survival was 11.5 months. One year survival rate was 30.02 %. Median duration of 12 effective patients were 5.3 months. Median survival of effective patients and non-effective was 11.8 and 8.5 months respectively （P 〈0.05）. Grade 3/4 neurosensory toxicity occurred in 14.81% of patients, dian＇hea, mucositis, Hematologic toxicity were minimal. Conclusion The effective of FOLFOX4 which seems beneficial as first-line therapy in advanced colorectalcance has a high effective rate with acceptable toxicity.

关 键 词：草酸铂 亚叶酸钙 5-氟尿嘧啶 结直肠癌 

分 类 号：R735.3[医药卫生—肿瘤]