离子通道在肺动脉的分布及在低氧肺血管收缩反应中的作用  

Distribution of Ion Channels in Pulmonary Arterial Smooth Muscle Cells and Their Roles in Hypoxia Pulmonary Vasoconstriction

作　　者：胡颖[1] 格日力[1] 

机构地区：[1]青海大学高原医学研究中心,西宁810001

出　　处：《生理科学进展》2006年第2期113-116,共4页Progress in Physiological Sciences

基　　金：国家自然科学基金(30260034);青海省科技厅院士基金(2001-5-801)资助课题

摘　　要：低氧性肺血管收缩反应(HPV)是指在急性低氧时,肺泡氧分压降到某一临界值,肺血管发生的快速、可逆的收缩反应,以纠正肺泡通气/灌流的不匹配。HPV的发生与肺动脉平滑肌细胞上K+、Ca2+、C l-通道的状态密切相关,而这些通道在不同部位的肺动脉上分布存在差异,因此不同部位的肺动脉在低氧中所表现的收缩反应程度也不同,本综述将对上述通道在肺动脉上的分布特点及其在HPV中的作用做一总结。Hypoxic pulmonary vasoconstriction （HPV） is the rapid, reversible increase in pulmonary vascular resistance that occurs when the alveolar oxygen tension falls below a threshold level, thereby achieving ventilation/perfusion matching. HPV is closely related to the state of K ^＋ , Ca^2＋ and Cl^- channels in pulmonary arterial smooth muscle cells, which distribute heterogenously along the longitude of pulmonary artery tree, and cause heterogenous vasoconstriction response in different part of pulmonary artery in HPV. In this review we summarize current knowledge about the distribution of these ion channels and their roles in HPV.

关 键 词：低氧 肺血管收缩 离子通道 

分 类 号：Q25[生物学—细胞生物学]