高强度聚焦超声热疗联合消积止痛散对胰腺癌患血清血管内皮生长因子的影响及意义  

Effect and significance of combination of high intensity focused ultrasound and xiaoji zhitong san on serum vascular endothelial growth factor in patients with pancreatic carcinoma

作　　者：葛信国[1] 王缨[2] 史兵伟[2] 

机构地区：[1]南京中医药大学,江苏省南京市210029 [2]常州市中医医院血液肿瘤科,江苏省常州市213003

出　　处：《中国临床康复》2006年第15期82-84,共3页Chinese Journal of Clinical Rehabilitation

基　　金：江苏省中医药管理局基金资助项目(苏卫中医科[2001]19号H-064)~~

摘　　要：目的:观察高强度聚焦超声热疗联合中药消积止痛散对胰腺癌患者血管内皮生长因子的影响。方法:纳入2001-01/2004-12常州中医院、常州第一人民医院肿瘤科门诊或入院胰腺癌患者61例,男42例,女19例;随机分为观察组31例和对照组30例。观察组采用高强度聚焦超声热疗联合中药消积止痛散治疗(中药消积止痛散为天江制药厂提供的配方颗粒,由全蝎0.5g,蛇六谷3.0g,仙鹤草2.0g,土鳖虫1.0g,粉防己0.5g组成)。热疗两次治疗间隔48h以上。每例患者接受3～12次高强度聚焦超声热疗治疗,平均6次;配合服用消积止痛散3.5g/次,2次/d,28d为1周期,连用两周期。对照组30例采用吉西他滨(商品名泽菲,江苏豪森药业股份有限公司生产,批号:040902,1.0g/支,粉针剂)化疗,吉西他滨1.0g/m2(第1,8,15天)或1.0g/m2(第1,8天)加5-FU350mg/m2(第1～5天),每4周重复1次,至少两个周期。采用双抗体夹心ELISA法测定两组患者治疗前后血清血管内皮生长因子的含量,并比较变化。结果:参与观察的胰腺癌患者61例全部进入结果分析。①观察组和对照组治疗前血清血管内皮生长因子含量比较,差异无显著性意义[(531.99±561.67),(491.07±483.68)ng/L;t=0.30,P>0.05]。②治疗后,观察组血清血管内皮生长因子含量较治疗前明显降低,差异有显著性意义[(285.40±323.13)ng/L,t=2.12,P<0.05],对照组较治疗前略上升,但差异无显著性意义[(285.40±323.13)ng/L,t=0.41,P>0.05]。③治疗后观察组血清血管内皮生长因子含量较对照组明显降低,差异有显著性意义(t=2.55,P<0.05)。结论:与吉西他滨化疗比较,高强度聚焦超声热疗联合中药消积止痛散治疗胰腺癌可明显降低患者血清血管内皮生长因子水平。AIM： To investigate the effect of combination of high intensity focused ul- trasound and xiaoji zhitong san on serum vascular endothelial growth factor （VEGF） in patients with pancreatic carcinoma METHODS： Totally 61 patients with pancreatic carcinoma including 42 males and 19 females were selected from Tumor Department of Changzhou Hospital of Traditional Chinese Medicine and the First People＇s Hospital of Changzhou between January 2001 and December 2004. All patients were divided randomly into observational group （n=31） and control group （n=30）. Patients in observational group were treated with combination of high intensity focused ultrasound and xiaoji zhitong san （provided by Tianjiang Pharmaceutical Factory, consisted of quanxie 0.5 g, sheliugu 3.0 g, xianhecao 2.0 g, tubiechong 1.0 g, and fenfanji 0.5 g） for twice with the interval above 48 hours. Each patient suffered from high intensity focused ultrasound for 3-12 times with the average of 6 times, and received 3.5 g once oxiaoji zhitong san twice a day for 28 days as a course for 2 successive courses. Patients in control group were treated with gemcitabinc （commercial name： zefei, provided by jiangsu Haosen Pharmaceutical Limited Company, batch number：. 040902, 1.0 g/branch, powder preparation）. 1.0 g/m^2 gemcitabine （1^th, 8^th and 15^th days） or 1.0 g/m^2 （1^th and 8^th days） mixed with 350 mg/m^2 5-FU （from first day to fifth day） were used once every four weeks for 2 course at least. Contents of serum VEGF were measured and compared before and after treatment with double-antibody-sandwich enzyme-linked immunoadserdent assay （ELISA）. RESULTS： Totally 61 patients with pancreatic carcinoma entered the final analysis. ① Contents of serum VEGF in observational group were not significant differences from those in control group before treatment [（531.99±561,67）, （491.07±483.68） rig/L; t=0.30, P 〉 0.05].② Contents of serum VEGF in observational group was lower after treatment than those befo

关 键 词：高温 诱发/方法 肿瘤/治疗 复方合剂 血管内皮生长因子类/代谢 胰腺肿瘤 

分 类 号：R730.5[医药卫生—肿瘤]