新生儿缺氧缺血性脑病血浆ET-1与血清NSE动态变化及相关性的研究  

Study on the Dynamic Changes of Plasma ET-1 and Serum NSE Levels in Neonates with Hypoxic Ischemic Encephalopathy

作　　者：周名雄[1] 张新路[2] 张士发[1] 茅双根[1] 徐国成[1] 

机构地区：[1]皖南医学院弋矶山医院儿科,241001 [2]皖南医学院弋矶山医院核医学科

出　　处：《放射免疫学杂志》2006年第2期86-87,共2页Journal of Radioimmanology

摘　　要：目的:探讨新生儿缺氧缺血性脑病(Hypoxic-ischemicencephalopathy,HIE)血浆内皮素(Endothlin,ET)与血清神经元特异性烯醇化酶(Neuronspeificenolase,NSE)动态变化及相关性。方法:采用放射免疫分析动态测定32例HIE新生儿生后24h、3d、7d血浆ET-1和血清NSE水平,并以30例正常新生儿(生后24h)为正常对照组。结果:HIE新生儿血浆ET-1、血清NSE浓度在生后24h内分别为(88.17±19.75)pg/ml,(26.40±12.74)ng/ml显著高于对照组(分别为52.81±12.11pg/ml,14.35±3.11ng/ml);3d开始下降,血浆ET-1、血清NSE浓度分别为(73.77±22.86pg/ml,19.86±7.04ng/ml)与生后24h比较有显著性差异(P均<0.05);7d,HIE新生儿血浆ET-1(59.49±20.64)pg/ml,血清NSE(15.40±3.36)ng/ml与对照组比较无显著差异(P均>0.05)。血浆ET-1与血清NSE呈正相关(r=0.550,P<0.05)。结论:血浆ET-1动态变化在新生儿HIE的发病机理有着重要的作用,NSE释放与ET-1的动态变化相关。Objective To investigate the dynamic changes of plasma endothelin - 1 （ET - 1 ） and serum neuron specific enolase （NSE） levels in neonates with hypoxic ischemic encephalopathy （HIE）. Methods Serum NSE and plasma ET - 1 levels were dynamically measured with RIA in 32 full ferm neonates with HIE on d1 （24h）, d3 and d7 as well as in 30 controls （ normal neonates at 24h）. Results At 24h after birth, the plasma ET - 1 and serum NSE level in the neonates with HIE were significantly higher than those in the controls （88.17 ± 19.75pg/ml vs 52.81 ± 12.11 pg/ml and 26.40 ± 2.74 ng/ml vs 14.35 ± 3.11 ng/ml respectively）. The levels dropped much on d3 but remained significantly higher than those in controls （73.77 ± 22.86pg/ml and 19.86 ± 7.04ng/ ml）. The levels dropped further and on d7 they were not significantly different from those in the controls （59.49 ±20.64pg/ml and 15.40±3.36pg/ml）. Levels of ET-1 and NSE were mutually positively correlated （r=0.550, P〈0.05）. Conclusion ET-1 and NSE were markers of severity and outcome of hypoxic ischemic encephalopathy.

关 键 词：缺氧缺血性脑病 内皮素-1 神经元特异性烯醇化酶新生儿 

分 类 号：R734.204[医药卫生—肿瘤] R722.12[医药卫生—临床医学]