CD44V6、EGFR、MMP-9在宫颈鳞癌组织中的表达及其意义  

The Expression and Significance of CD44V6、EGFR and Mmp-9 in Squamous Cell Cacinoma of the Cervix

作　　者：于晓红[1] 熊勇[1] 魏宝秀[1] 万磊[1] 秦贇娜[1] 付秋风[1] 

机构地区：[1]江西省妇幼保健院病理科,江西南昌330006

出　　处：《实用临床医学（江西）》2006年第4期9-12,共4页Practical Clinical Medicine

摘　　要：目的:探讨CD44V6、EGFR和MMP-9在正常宫颈组织、宫颈上皮内瘤变及宫颈鳞癌组织中的表达及其意义。方法:采用免疫组织化学方法检测20例正常宫颈组织、50例宫颈上皮内瘤变及168例宫颈鳞癌患者组织中的CD44V6、EGFR、MMP-9的水平。结果:CD44V6、EGFR和MMP-9蛋白在宫颈鳞癌组及CIN组中的阳性表达率分别为68.45%、61.90%、70.83%和36.00%、44.00%、34.00%。CD44V6、EGFR和MMP-9的蛋白表达与宫颈鳞癌的临床分期无关(r分别为0.058、0.073、0.005,P均>0.05),但与病理组织学分级、淋巴结转移呈正相关(r分别为0.358、0.269、0.217和0.439、0.338、0.301,P均<0.05)。结论:CD44V6、EGFR和MMP-9可能是宫颈癌发生的相关基因,与肿瘤的发展和转移有关。联合检测CD44V6、EGFR和MMP-9的表达可作为宫颈癌早期诊断、转移潜能和预后的判断。Objective：To investigate the expression of CD44V6,EGFR and MMP-9 in normal cervical tissues,cervical intraepithelial neoplasia（CIN） and squamous cell carcinoma of the cervix and explore its clinical significance. Methods： The expressions of CD44V6,EGFR and MMP-9 in 20 cases of normal cervical tissues,50 cases of CIN and 168 cases of squamous cell cacinoma of the cervix were defected by immunohistochemical technique. Results：The positive rates of expression CD44V6,EGFR and MMP-9 in cervical carcinoma and CIN tissues were 68. 45%, 61.90%, 70.83% and 36. 00%, 44. 00%, 34.00%, respectively. The expression of CD44V6, EGFR and MMP-9 proteins were no relationship with clinical stage（P〉0.05）, but were all well correlated with pathological grade, lymph node metastasis （P 〈 0. 05）. Conclusion： CD44V6, EGFR and MMP-9 may be correlated with occurrence,development and metastasis of cervical carcinoma. Examination of the expression of CD44V6,EGFR and mmp-9 may be helpful to the evaluation of metastasis potential and prognosis of early cervical carcinoma.

关 键 词：宫颈肿瘤 细胞黏附分子 表皮生长因子受体 金属蛋白酶类 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤] R446.62[医药卫生—临床医学]