转录因子Snail的作用机制及其生理功能  

The Mechanism and Physiological Function of Transcriptional Factor Snail

作　　者：胡士军[1] 马兴红[1] 杨增明[1] 

机构地区：[1]东北农业大学生命科学学院,哈尔滨150030

出　　处：《细胞生物学杂志》2006年第2期160-164,共5页Chinese Journal of Cell Biology

基　　金：国家自然科学基金资助项目(No.30270163)~~

摘　　要：Snail为起负调节作用的锌指转录因子,其序列和功能在不同种属动物中十分保守。Snail超家族成员在胚胎着床、胚胎发生、肿瘤发生、细胞命运决定、细胞周期调控、左右不对称发育及创伤愈合等生理或病理过程发挥重要作用。对Snail的进一步研究,不仅可以阐明Snail超家族的作用机制,而且可以为探究Snail相关的肿瘤治疗策略提供重要的理论基础。Snail is a transcription factor of the zinc-finger type as a negatively regulator, and very conservative in different species. Snail superfamily plays important roles in the physiological and pathological progresses, such as embryo implantation, embryogenesis, carcinogenesis, cell fate determination, cell cycle regulation, left-fight asymmetry, wound healing and so on. Further study on Snail not only illuminates the functions of Snail superfamily, but also offers theoretical foundations for exploring tumor therapeutic strategies.

关 键 词：SNAIL 锌指 上皮细胞-间充质细胞转换 胚胎发生 肿瘤发生 

分 类 号：Q753[生物学—分子生物学] TS202.3[轻工技术与工程—食品科学]