异位错构瘤性胸腺瘤1例及文献复习  

Ectopic hamartomatous thymoma: a case report and review of literature

作　　者：房新志[1] 赵峰[1] 柴敏秀[1] 李景英[1] 韦薇[1] 

机构地区：[1]新疆医科大学附属肿瘤医院病理科,乌鲁木齐830011

出　　处：《临床与实验病理学杂志》2006年第2期208-210,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨异位错构瘤性胸腺瘤(EHT)的临床及病理特征。方法复习1例EHT患者的临床病史、肿瘤组织的病理形态和免疫表型及相关文献。结果患者男性,56岁,以左胸锁关节下方皮下肿块为主要表现。肿瘤包膜完整,切面以灰白色实性为主。镜下表现复杂,以束状及平行排列的梭形细胞为主,混合有上皮成分及成熟的脂肪细胞等。瘤细胞均不具异型性,也缺乏坏死。免疫组化显示梭形细胞CK阳性,灶状细胞MSA阳性,S-100蛋白、desm in、vim entin和CD34均呈阴性。结论EHT有独特的发病部位和形态学表现,对梭形细胞上皮本质的认识是正确诊断的关键。Purpose To study the clinico-pathological characteristics of ectopic hamartomatous thymoma. Methods With review of the literature, the clinical history, histopathological changes and immunohistochemical expression were investigated and reviewed in one case of ectopic hamartomatous thymoma. Results A 56-year-old man presented with a subcutaneous mass adjacent to the left sternoclavicular joint region, which had predominant spindle cells, a small number of epithelial component and mature adipose tissue; the varied components lacked atypia and necrosis. In immunohistochemistry, both the spindle cell and epithelial components stained diffusely and strongly for cytokeratin, a proportion of the spindle cells were immunoreactive for MSA. Staining for S-100 protein, desmin, vimentin and CD34 was negative in spindle ceils as well as epithelial ceils. Conclusions Ectopic hamartomatous thymoma has a unique histological appearance as well as sites of involvement. Well recognition of the spindle cell as epithelial nature is a key to correctly diagnose this rare tumor.

关 键 词：胸腺瘤/病理学 异位 错构瘤 免疫组织化学 

分 类 号：R736.3[医药卫生—肿瘤]