大鼠部分活体肝移植动物模型制备技术再探讨  

Technique established for animal model of partial living donor liver transplantation in rat

作　　者：王红鲜[1] 张培建[2] 王跃全[3] 胥连生[1] 

机构地区：[1]青海大学医学院临床医学系,青海西宁810001 [2]扬州大学医学院,扬州大学第二临床医学院普外科,江苏扬州225001 [3]青海大学医学院附属医院普外科,青海西宁810001

出　　处：《中国现代医学杂志》2006年第8期1160-1163,共4页China Journal of Modern Medicine

基　　金：江苏省卫生厅医学重点学科(实验室)开放课题(No:WK200222)

摘　　要：目的建立大鼠部分活体肝移植可靠、稳定的动物模型。方法应用改良的“二套袖法”,在部分活体肝移植大鼠的筛选、手术操作技巧和术前、术后处理等方面进行了改进。结果肝移植大鼠术后1周以上存活率67%。结论改进的大鼠部分活体肝移植术成活率高,重复性好,可做为部分活体肝移植有关实验研究的可靠、稳定的动物模型。[Objects] To enhance further survival rate of rat partial LDLT, animal model in rat partial LDLT was established reliably and stably. [Methods] Modified cuff for two vascular anastomoses with rigid selection in rats, improved surgical techniques, pre-and post-operative management. [Results] The survival rate more than one week was 67%. [Conclusion] Because of highly survival rate and reproduction, improved model of two-cuff can be used as the reliably and stably experimental animal model in rat partial LDLT.

关 键 词：活体肝移植 动物模型 大鼠 

分 类 号：R-332[医药卫生]