巨大肾癌经肾动脉介入性治疗  

Interventional therapy via renal artery for giant carcinomas of kidney

作　　者：黄福贵[1] 李彦兵[1] 张敬一[1] 祁欣[1] 刘冬梅[1] 

机构地区：[1]沈阳军区总医院介入科,辽宁沈阳110016

出　　处：《中国现代医学杂志》2006年第8期1207-1209,共3页China Journal of Modern Medicine

摘　　要：目的评价巨大肾癌经动脉灌注栓塞技术的疗效。方法对32例巨大肾癌经肾动脉灌注栓塞术,灌注抗癌药物为表阿霉素30～40mg。丝裂霉素20～30mg和5-FU500mg。应用无水酒精、鱼肝油酸钠和碘油加明胶海绵施行肾动脉栓塞。结果所有病例均成功地施行经肾动脉灌注栓塞术,8例实施手术切除,术中可见肿瘤血供基本中断,病理检查见肿瘤细胞坏死明显,周边有少许炎性淋巴细胞及不同程度纤维增生,毛细血管栓塞。临床症状缓解率87.5%(28/32),肿瘤缩小率91.0%(29/32),6个月及1、2、3年生存率分别为78.1%、68.8%、46.9%和31.3%,平均生存期24.5个月,最长58个月。结论经肾动脉联合灌注化疗及栓塞治疗巨大肾癌,大部分肿瘤都有不同程度坏死缩小,临床疗效较好。[Objective] To evaluate the efficacy of infusion and embolizafion via renal artery for giant carcinomas of the kidney. [Method] Thirty-two subjects with giant carcinomas of the kidney were infused via renal artery with mitomycin （20-30 mg）, epirubicin （30-40 mg） and 5-FU （500 mg） and embolized by anhydrous alcohol, sodium morrhuate, and lipiodol plus gelatin sponge, [Results] The all infusion and embolization via renal artery was suecessfully administered and the surgical section was perforated on eight patients. Little or no blood supply to the tumor was seen in operation. The main pathological findings were marked necrosis of tumor cells with inflammatory cell infiltration around and fibrous proliferation as wee as capillary embolizafion. Clinical symptoms were remitted in 87.5%（28/32） and the sizes of the tumor decreased in 91%（29/32）. The survival rates of 6-month, 1-, 2- and 3-year were respectively 78.1%, 68.8%, 46.9%, 31.3%. The mean survival time was 24.5 months with the longest of 58 months. [Conclusion] Combination of infusion and embolization through renal artery for giant carcinomas of kidney has better efficacy in diminution and necrosis of the tumors at different extents.

关 键 词：肾细胞癌 动脉栓塞 化疗 

分 类 号：R737.11[医药卫生—肿瘤]