2002年～2004年我院抗菌药物的使用与细菌耐药性分析  

Analysis on Antibacterial Drug Use and Bacterial Drug Resistance between 2002 and 2004

作　　者：杨晓军[1] 吴万征[1] 吴雪梅[1] 戴湘春[1] 谭玲[1] 

机构地区：[1]广东医学院附属医院,湛江市524001

出　　处：《中国药房》2006年第8期594-596,共3页China Pharmacy

摘　　要：目的:探讨我院抗菌药物使用量与细菌耐药性之间的关系。方法:统计2002年～2004年5类抗菌药物的用药频度,并对用药频度和细菌耐药性进行分析。结果:3年来抗菌药物的总用药频度值增长了47.14%;2004年,4种主要病原菌对9种常用抗菌药物的耐药率大于44%;阿莫西林/克拉维酸钾、氨苄西林钠/舒巴坦钠、头孢哌酮钠/舒巴坦钠3年来用药频度分别增长4倍、19.8倍、7倍,病原菌对其耐药率也明显提高,其中金黄色葡萄球菌的耐药率增加22%以上。结论:医院应多方面加强抗菌药物使用管理,减少细菌耐药性的发生。OBJECTIVE： To discuss the correlation between antibacterial drug use and the bacterial drug resistance in the hospital where the authors work. METHODS： The DDDs of antibacterials during the period from 2002 to 2004 were counted, and the correlation between DDDs and bacterial drug resistance was analyzed.RESULTS： The total DDD of the antibacterials increased by 47.14% in this period. To 2004, the resistance rates of 4 major pathogens to 9 commonly used categories of antibacterials were more than 44%. The DDDs of amoxicillin/clavulanate potassium,ampicillin sodium/sulbactam sodium, cefoperazone sodium/sulbactam sodium increased by 4, 19.8 and 7 times, respectively in the 3 years, the resistance rates of pathogens to which also evidently increased, among which staphylococcus aureus increased by over 22% .CONCLUSION： The hospital should strengthen the administration of antibacterial drug use in many ways to reduce the bacterial drug resistance.

关 键 词：抗菌药物 耐药性 药敏试验 合理用药 

分 类 号：R978.1[医药卫生—药品] R969.3[医药卫生—药学]