肝硬化患者Q-T间期延长临床意义  

Clinical significance of Q-T prolongation in hepatic cirrhosis.

作　　者：汪明涛[1] 陈范嵘[1] 郭继兵[1] 李晓虹[1] 朱春燕[1] 

机构地区：[1]上海市普陀区人民医院消化科,上海200060

出　　处：《华中医学杂志》2006年第2期123-124,共2页Central China Medical Journal

摘　　要：目的探讨肝硬化患者Q-T间期(Q-Tc)变化及Q-Tc与肝硬化的病因、严重程度的关系。方法检测94例肝硬化患者与50例非肝硬化患者心电图Q-Tc、凝血酶原时间(PT)、血清白蛋白(ALB)、血清总胆红素(TBIL)等指标。组间比较Q-Tc的变化及肝功能不同Child分级间Q-Tc的异常率。结果肝硬化组Q-Tc为(435±40)ms,非肝硬化组为(405±33)ms,两组比较有极显著性差异(P<0.01);肝硬化组中ChildC级的Q-Tc异常率(68.8%)与A级(33.3%)比较有极显著性差异(P<0.01);单因素直线相关分析结果显示Q-Tc与Child积分呈正相关(r=0.32,P<0.01)。多元回归分析结果Child积分与Q-Tc相关。结论随肝硬化病情加重,Q-Tc异常率升高,Q-Tc延长与严重心律失常及猝死有关;对肝硬化病情严重者行动态心电图检测,纠正异常Q-Tc对肝硬化患者是必要的。Objective To investigate the clinical significance of Q-T prolongation and the relationship between corrective Q-T interval （Q-Tc） and the etiology and severity of hepatic cirrhosis. Method 94 eases of hepatic cirrhosis and 50 control subjects were studied. Rate-corrected Q-Tc, liver function tests, Child-Pugh score and electrolytes were assessed. Correlation coefficiencies were derived by linear regression analysis. Variables were correlated with Q-Tc by multiple regression analysis. Result Q-Tc was longer in patients with cirrhosis than that in controls [（435 ± 40）ms Vs （405 ± 33）ms （P〈0. 01）] and prolonged in 49 patients （52. 1%） and in 6 controls （12. 0 %） . Multiple regression analysis showed only Child-Pugh score was independently correlated with Q-Tc duration. Conclusion Q-Tc are frequently prolonged in patients with cirrhosis and worsens in patients with the severity of the disease. Since abnormal Q-Tc may be correlated with severe arrhythmia and the sudden death. Close monitor of ECG changes in severe cirrhotie patients is necessary.

关 键 词：肝硬化 Q-T间期 肝功能 

分 类 号：R575.2[医药卫生—消化系统] R540.41[医药卫生—内科学]