多发性硬化磁共振氢波谱的初步研究  

Proton MR spectroscopy in multiple sclerosis:a preliminary study

作　　者：胡卫东[1] 项立[2] 范义[1] 刘静华[3] 娄明武[1] 杨广夫[1] 

机构地区：[1]深圳市龙岗中心医院介入影像科,518116 [2]深圳市龙岗中心医院消化内科,518116 [3]深圳市龙岗中心医院功能科,518116

出　　处：《中国医师进修杂志》2006年第4期20-21,30,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的研究多发性硬化(MS)氢质子波谱(1HMRS)的特征及其代谢物变化规律,探讨MRS在多发性硬化诊断中的应用价值。方法应用PhilipsInteraNovaDual1.5T超导MR机分别对急性与慢性多发性硬化各8例患者进行常规MR及MRS扫描并与12例正常志愿者对应部位二维多发性硬化氢质子波谱影像(2D1HMRSI)进行对比研究。结果急性期表现为显著降低的NAA峰、Cr峰及NAA/Pcr值,而Pcr、Cho、Lac和MI升高,慢性期Cho、Cr、Pcr、MI恢复正常,Lac峰消失,NAA及NAA/Pcr值下降。结论MRS作为一种无创伤活体显示组织代谢的影像学方法具有广阔的应用前景。Objective To study the characteristics and the regularities of the metabolites in multiple sclerosis（MS） with proton MR spectroscopy, and to investigate the clinical value of MR spectroscopy in multiple sclerosis. Methods The findings of conventional MRI and of HMRSI from 8 cases of acute and chronic multiple sclerosis as and from 12 normal volunteers were comparatively analyzed, its all were using Philips Intera Nova Dual 1.5T MR system. Results ^1HMRSI of all multiple sclerosis as revealed different spectral.peaks, including reduced N-acetylaspartate （NAA）, creatine （Cr） and NAA/Pcr, prominent phosphorcreatine （Per）, prominent choline （Cho）, prominent lactate, （Lae）, and prominent myoinositol （MI） in the acute MS. Normal Cho,Cr,Pcr,MI,void Lip reduced NAA and NAA/Pcr, in the chronic MS. Conclusion MRS is a noninvasive and accurate procedure, it can reveal organic metabolizability and have capacious foreground.

关 键 词：多发性硬化 磁共振成像 磁共振波谱学 

分 类 号：R744.51[医药卫生—神经病学与精神病学] R742.5[医药卫生—临床医学]