利培酮和氯丙嗪治疗时血糖代谢变化  

Metabolism of the blood-glucose that affected by chlorpromazine or risperidone treatment

作　　者：瞿正万[1] 陈美娣[1] 古嘉琪[1] 傅伟忠[1] 王涛[1] 顾立铭[1] 江琦[1] 王豪[1] 袁杰[1] 杨振东[1] 李亚明[1] 胡承平[1] 曹凤妹[1] 瞿嘉兴[1] 尹端六[2] 陆明康[3] 

机构地区：[1]上海市浦东新区精神卫生中心,200122 [2]上海第二医科大学附属瑞金医院 [3]上海市精神卫生中心

出　　处：《临床精神医学杂志》2006年第2期68-70,共3页Journal of Clinical Psychiatry

基　　金：浦东新区社会发展局课题赞助项目(PW2003-A3)

摘　　要：目的:研究使用抗精神病药影响血糖代谢的特点。方法:198例未曾治疗或停药3个月以上的精神分裂症住院患者给予氯丙嗪或利培酮治疗。于入院时及治疗1、2、3和6个月时检测血糖浓度。结果:氯丙嗪组治疗2个月餐后2 h糖耐量试验(2hPG)、6个月后糖化血红蛋白(HbA1C)浓度均明显高于治疗前。治疗6个月血葡萄糖调节受损(IGR),氯丙嗪组有15.54%,利培酮组有7.37%;≥40岁者2hPG和HbA1C明显高于<40岁者。结论:2hPG和HbA1C浓度增高是糖代谢异常的早期表现,早期干预有利于防止IGR。Objeetive： To study the characteristics of the blood-glucose metabolism that affected by the antipsychotics therapy. Method：198 schizophrenic inpatients, who were untreated or drug stopped beyond 3 months, were randomly treated by chlorpromazine or risperidone and their blood-glucosc were tested at the admission, 1,2,3, and 6 months after treatment. Results：The concentrations of two hours oral glueose tolerance test （2hPG） at two months after treatment,and the concentrations of glycosylated hemoglobin （HbA1C） at six months ＇after treatment in chlorpromazine group were obviously higher than those at the admission. At the 6 months ＂after treatment, 15.54% patients were affected by the impaired glucose regulation （IGR） in chlorpromazine group,and 7.37% in risperidone group. The concentration of 2hPG and HbA1C of patients who were aged over 40 years old were both significantly higher than those who were younger than 40 years old. Conelusion：The increased concentration of 2hPG and HbA1C can be an earlier performance of abnormal blood-glucose metabolism, and the early intervention may prevent from IGR.

关 键 词：利培酮 氯丙嗪 血糖 代谢 

分 类 号：R749.053[医药卫生—神经病学与精神病学]