急性高原脑水肿患者血浆白细胞介素-6的变化  

CHANGES OF INTERLEUKIN-6 IN PATIENTS WITH ACUTE HIGH ALTITUDE CEREBRAL EDEMA

作　　者：陈云天[1] 胡颖[1] 靳国恩[1] 张雪峰 张梅 格日力[1] 

机构地区：[1]青海大学高原医学研究中心,西宁810001 [2]青海省格尔木市人民医院

出　　处：《解放军预防医学杂志》2006年第2期92-94,共3页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：目的探讨急性高原脑水肿(HACE)和急性高原肺水肿(HAPE)与血浆白细胞介素-6(IL-6)之间的关系。方法对130名登山队员进行调查,统计该人群HACE和HAPE的患病率,并采用放射免疫法在海拔2 800 m地方测定7人血清中的IL-6,在海拔5 050 m地方测定27人血清中的IL-6(不包括海拔2 800 m地方测定的7人),并进行动脉血氧饱和度(SaO2)的测量,以评价他们的缺氧程度。结果海拔5 050 m地方的HACE总患病率是3.8%,HACE同时伴HAPE的患病率是2.3%,单纯HACE的患病率是1.5%。HACE患者其中包括并发HAPE患者的IL-6水平为(144.06±29.43)ng.mL-1,明显高于海拔2 800 m地方的正常组〔(70.88±11.59)ng.mL-1〕(P<0.01)和海拔5 050 m地方的正常组〔(89.35±36.29)ng.mL-1〕(P<0.01);SaO2为(50.20±3.96)%,显著低于海拔2 800 m地方的正常组〔(90.14±2.54)%〕(P<0.01)和5 050 m地方的正常组〔(75.55±6.33)%〕(P<0.01)。结论在高原低氧状态下,IL-6因子及其介导的炎症反应参与了HACE和HAPE的发病过程。Objective To explore the relationship of plasma interleukin - 6 in patients with acute high altitude cerebral edema （HACE） and pulmonary edema （HAPE）. Methods One hundred and thirty climbers from sea level were investigated. Serum IL - 6 level in 7 subjects at 2 800 m, and in 27 subjects at 5 050 m by using radioimmunoassay, as well as their arterial oxygen saturation were derermined . Results The total morbidity of HACE was 3.8%, the morbidity of HACE with HAPE were 2.3 %, the morbidity of simple HACE was 1.5 % at 5 050 m. The IL - 6 levels in patients with HACE [ （144.06 ± 29.43）ng· mL^-1 ]were higher than that in normal subjects at 5 050 m [ （89.35 ± 36.29） ng· mL^-1 （P〈0.01）, and that in normal subjects at 2 800 m [（70.88± 11.59） ng·mL^-1 （P〈0.01）. Arterial oxygen saturation of HACE subjects （50.20 ± 3.96）% was significantly lower than that of normal subjects at 5 050 m[ （75.55 ± 6.33） % ] （ P 〈 0.01 ） and at 2 800 m [ （90.14 ± 2.54） % ] （ P 〈 0.01 ）. Conclusion IL - 6 and its mediated - inflammation may take part in the pathogenesis of HACE and HAPE in high altitude environment.

关 键 词：高原 急性高原脑水肿 急性高原肺水肿 白细胞介素-6 

分 类 号：R135.6[医药卫生—劳动卫生]