实验性牙移动三叉神经节内神经生长因子受体mRNA的改变  

Changes of NGF Receptor-TrkA mRNA Level in Trigeminal Ganglion during Experimental Tooth Movement in the Rat.

作　　者：徐娟[1] 刘洪臣[1] 袁维秀[2] 黄旭明[1] 

机构地区：[1]解放军总医院口腔科,北京100853 [2]解放军总医院麻醉科,北京100853

出　　处：《口腔医学研究》2006年第2期120-122,共3页Journal of Oral Science Research

基　　金：国家自然科学基金资助(编号:30572066);全军医药卫生科研基金资助(编号:02M013)

摘　　要：目的:观察实验性牙移动时,NGF受体-TrkA mRNA在三叉神经节内的改变,方法:采用RT-PCR方法研究实验性牙移动后,三叉神经节内TrkA mRNA表达的改变。结果:实验性牙移动后6 h,实验侧TrkA mRNA的表达开始增加;24 h、3 d,1周实验组三叉神经节内TrkA mRNA的表达强于对照组;2周组,实验侧TrkA mRNA的表达恢复至正常水平。结论:实验性牙移动时,三叉神经节内TrkA的表达升高。Objective： To observe the changes of TrkA mRNA level in the trigeminal ganglion during the experimental tooth movement. Methods： The expressions of TrkA mRNA in trigeminal ganglion were tested by RT - PCR technology. Results： Comparing to the control group, the gene expression of the high - affinity NGF receptor, TrkA, was upregulated during the experimental tooth movement to a different extent and in a time - dependent manner. Expression of TrkA mRNA increased after 6 hours experimental tooth movement, then reached the highest at 24 hours and returned to control level after 2 weekes. Conclusion： The expression of TrkA increases in trgeminal ganglion after the experimental tooth movement.

关 键 词：实验性牙移动 神经生长因子受体 

分 类 号：R780.2[医药卫生—口腔医学]