多焦视诱发电位在青光眼视野损害检测中的应用  

Multifocal visual evoked potential in the detection of glaucomatous field defects

作　　者：孙传宾[1] 陈晓明[2] 

机构地区：[1]温州医学院附属眼视光医院,325003 [2]四川大学华西医院眼科中心

出　　处：《眼科》2006年第2期122-126,共5页Ophthalmology in China

摘　　要：目的了解多焦视诱发电位(mfVEP)在青光眼视野损害检测中的作用。设计病例对照研究。研究对象 20例正常人和20例原发性青光眼患者。方法对20例正常人和20例原发性青光眼患者应用RETIscan mfVEP记录系统3．20行检查, 分别测量所有受试者mfVEP每一位点记录曲线的振幅,并计算受试者的双眼视网膜反应不对称系数(RAC)。比较青光眼患者 mfVEP检查的暗点与OCTOPUS 101型自动视野计G2程序检查的视野缺损区的对应性。主要指标振幅、RAC。结果在与自动视野计检查发现的视野缺损相对应的部位,90％患眼的mfVEP表现为至少3个相邻位点的振幅降低或RAC超出正常人数据库均数的2倍标准差(SD)。其中63％患眼表现为至少3个相邻位点的振幅降低超出正常人均数的2 SD,70％患眼表现为至少3个相邻位点的RAC超出正常人均数的2 SD。有2例患者(2眼)的自动视野计检查结果正常,但mfVEP显示有视野异常。正常人中无一眼的mfVEP表现为视野异常。结论 mfVEP有可能作为青光眼视野损害的客观检查手段。Objective To evaluate the effect of multifocal visual evoked potential（mfVEP）on the detection of glaucomatous field defects. Design Case-controlled study. Participants 20 healthy individuals and 20 patients with primary glaucoma accepted mfVEP test. Methods 20 healthy individuals and 20 patients with primary glaucoma were tested with RETIscan multifocal VEP System 3.20 and OCTOPUS 101 automated perimetry G2 test program. Amplitudes were measured and interocular response asymmetry coefficient （RAC） was calculated for each site from all participants. The abnormal areas from mfVEP test were compared with field defects from automated perimetry. Main Outcome Measures Amplitude, RAC. Results 90% of suffered eyes showed at least 3 adjacent points had an amplitude decrease or RAC outside 2 standard deviations （SD） from healthy individual database, in which 63% showed at least 3 adjacent points had an amplitude decrease outside 2 SD from normal database while 70% showed at least 3 adjacent points had a RAC outside 2 SD from normal database. 2 patients （2 eyes ） had field defects in mfVEP though automated perimetry showed normal field. None of the healthy showd field defects in mfVEP test. Conclusions mfVEP could be used to detect field defects of glaucoma.

关 键 词：多焦视诱发电位 青光眼/诊断 视野 

分 类 号：R775[医药卫生—眼科]