红景天对博莱霉素致大鼠肺损伤治疗作用的研究  

The effect of rhodiola rosea L on rat lung injury induced by Bleomycin

作　　者：张智猷[1] 茹永新[2] 郭德安[1] 

机构地区：[1]天津中医学院第一附属医院放射科,天津300193 [2]中科院血研所电镜室,北京100864

出　　处：《中国中西医结合影像学杂志》2006年第2期88-91,共4页Chinese Imaging Journal of Integrated Traditional and Western Medicine

摘　　要：目的:通过对博莱霉素诱导的大鼠模型高分辨率CT图像和病理结果的对照分析,研究中药红景天对肺损伤不同时期炎症和纤维化过程的干预作用。方法:实验用大鼠分为四组即正常对照组、博莱霉素组、博莱霉素+红景天组、博莱霉素+激素组,实验组用博莱霉素(5mg/kg)经支气管灌注诱导形成大鼠肺损伤模型,在预设的时间点取一组大鼠进行HRCT扫描、肺Heitzman法固定及HE染色和胶原纤维VanGieson染色。结果:对处理组大鼠的HRCT连续观察发现博莱霉素组肺内病变呈明显的进行性发展,与病理切片的表现相一致;而博莱霉素+红景天组第3、7天影像改变轻于模型组,而第28天与模型组区别不大,病理显示第3天的病理改变明显轻于模型组,其他时间点红景天组病理改变与模型组接近。结论:红景天对博莱霉素致肺损伤早期急性炎症反应引起的急性肺水肿和出血有一定的抑制作用。Objective： To observe the effect of RRL on rat lung injury induced by BLM in various periods by comparing HRCT scan with pathologic finding. Methods： The lung injury modal of rats was made by intratracheal bleomycin （5mg/kg） and the rats were divided into control group, BLM group, BLM＋ RRL group and BLM＋MPD group. Following HRCT scan on a presenting time point, the lungs of rats underwent pathologic procedures. Results： Consistent with the pathologic findings, BLM group MSCT showed the pulmonary lesions aggravated progressively. On the 3^th , 7^th day, the image changes of the BLM＋RRL group were lighter than BLM group, but similar on the 28^th day except a little less density. Meanwhile, the pathology study illustrated the same result too. Conclusion： Rhodiola rosea L（RRL） had the ability to suppress edema, leakage and hemorrhage caused by acute inflammation in early stage on rat lung injury induced bv BLM.

关 键 词：红景天 博莱霉素 肺损伤 体层摄影术 X线计算机 

分 类 号：R285[医药卫生—中药学]