Expression of Ets-1 proto-oncoprotein in gastrointestinal stromal tumors, leiomyomas and schwannomas  

作　　者：Toshiyuki Nakayama Ayumi Yoshizaki Shinji Naito Chun Yang Wen Gabit Alipov Yuichi Yakata Ichiro Sekine 

机构地区：[1]Department of Molecular Pathology, Nagasaki University Graduate School of Biomedical Sciences,1-12-4 Sakamoto, Nagasaki 852-8523, Japan [2]Division of Pathology, Research Laboratory, National Ureshino Medical Center, Saga 843-0301, Japan [3]Department of Digestive Disease, Nanjing Drum Tower Hospital, Medical School of Nanjing University,Nanjing 210008, Jiangsu Province, China [4]Tissue and Histopathology Section, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan

出　　处：《World Journal of Gastroenterology》2006年第11期1743-1746,共4页世界胃肠病学杂志（英文版）

摘　　要：AIM： Gastrointestinal stromal tumors （GISTs） are rare. GISTs differ from other mesenchymal tumors of the gastrointestinal tract （e.g. leiornyomas and schwannomas）. The purpose of this study was to investigate the role of Ets-1 in the growth and differentiation of GISTs. METHODS： Twenty-eight GISTs, nine leiomyomas and six schwannomas were examined by immunohistochemical staining method for Ets-1 in this study. Specimens were selected from surgical pathology archival tissues at Nagasaki University Hospital. RESULTS： Ets-1 protein was expressed in the cytoplasm of cells in all of these tumors. Immunohistochemical staining revealed that 27 GISTs （96.4%）, six leiomyomas （66.7%）, and five schwannomas （83.3%） were positive for Ets-1. Ets-1 expression was statistically different between GISTs and leiomyomas （P〈0.005）. However, there was no correlation between Ets-1 expression and clinical risk categories. CONCLUSION： Ets-1 plays an important role in the growth and differentiation of GISTs, leiomyomas and schwannomas.瞄准：胃肠的基质肿瘤(大意) 是稀罕的。大意不同于胃肠道的另外的间充质的肿瘤(例如平滑肌瘤和 schwannomas ) 。这研究的目的是在大意的生长和区别调查 Ets-1 的角色。方法：28 大意，九个平滑肌瘤和六 schwannomas 被免疫检验为在这研究的 Ets-1 的组织化学的染色方法。标本从外科病理学被选择在长崎大学医院的档案的纸巾。结果：Ets-1 蛋白质这些肿瘤在所有在房间的细胞质被表示。染色的 Immunohistochemical 表明 27 大意(96.4%) ，六个平滑肌瘤(66.7%) ，和五 schwannomas (83.3%) 为 Ets-1 是积极的。Ets-1 表示在大意和平滑肌瘤(P<0.005 ) 之间是统计上不同的。然而，在 Ets-1 表示和临床的风险范畴之间没有关联。结论：Ets-1 在大意，平滑肌瘤和 schwannomas 的生长和区别起一个重要作用。

关 键 词：ETS-1 GISTS LEIOMYOMA Schwannoma Immunohistochemistry Risk category 

分 类 号：R735[医药卫生—肿瘤]