MUM1/IRF4在恶性淋巴瘤中的表达及其意义  

Expression of MUM1/IRF4 Protein and its Significance in Malignant Lymphoma

作　　者：陈愉[1] 蔡庆发[2] 赵彤[3] 吴炳绪[1] 陈美燕[1] 

机构地区：[1]中国人民解放军第九十五医院病理科,351100 [2]莆田学院附属医院病理科,351100 [3]南方医科大学病理教研室,510515

出　　处：《实用癌症杂志》2006年第1期17-19,共3页The Practical Journal of Cancer

基　　金：福建省自然科学基金资助项目(Z0516086)

摘　　要：目的通过检测恶性淋巴瘤组织中MUM1(multiple myeloma oncogene 1)/IRF4(interferon regulatory factor 4)蛋白的表达,探讨MUM1/IRF4在恶性淋巴瘤的诊断及细胞起源中的意义。方法应用免疫组织化学S-P法,检测84例恶性淋巴瘤标本中MUM1/IRF4蛋白的表达。结果恶性淋巴瘤MUM1蛋白总阳性表达率为66.7%(56/84),其中霍奇金淋巴瘤阳性表达率为100.0%(14/14),非霍奇金淋巴瘤阳性表达率为60.0%(42/70)。在70例非霍奇金淋巴瘤中,B细胞淋巴瘤阳性表达率为52.0%(26/50),T细胞淋巴瘤阳性表达率为80.0%(16/20)。结论霍奇金淋巴瘤H/RS细胞可能来源于B细胞,在B细胞淋巴瘤中MUM1的表达提示该细胞处于分化的终末阶段,在T细胞淋巴瘤中MUM1的表达可能与细胞的活化有关。Objective To investigate the expression of MUM1/IRF4 protein in malignant lymphoma and it＇s .significance. Methods The expression of MUM1/IRF4 protein was examined in 84 cases with malignant lymphoma by immunohistochemistry. Results Overall MUM1/IRF4 positivity in lymphoma was 66.7% （56/84）,Hodgkin＇.s lymphoma was completely positive（14/14）, while only 60.0% （42/70）cases of non-Hodgkin＇s lymphoma possessed MUM1 ＋ tumor cells, in 70 cases of non-Hodgkin＇s lymphoma, MUM1/IRF4 expressions was observed in 52.0% （26/50）of B cell lymphoma,80.0% （16/20）of T cell lymphoma. Conelusion These findings suggest that MUM1 is generally expressed in tumor cells originating fron Germinal Centers or post-Germinal Centers B cells,T cell lymphoma,MUM1/IRF4 positivity may represents the activated state of the cells.

关 键 词：MUM1/IRF4蛋白 淋巴瘤 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]