盐酸格拉司琼预防肝癌患者介入治疗后恶心呕吐的疗效观察  

Effect of Granisetron on Vomitting Caused by Transarterial Chemoembolization(TACE)

作　　者：寇光[1] 

机构地区：[1]江西省人民医院药剂科,330006

出　　处：《实用癌症杂志》2006年第1期79-80,共2页The Practical Journal of Cancer

摘　　要：目的探讨盐酸格拉司琼对预防肝癌患者介入治疗后引起的恶心、呕吐的疗效。方法将60例行介入治疗的患者随机分为格拉司琼治疗组(治疗组)和胃复安+安定对照组(对照组)。治疗组在介入治疗术中未灌注化疗药物前,通过导管向动脉内注射盐酸格拉司琼。对照组在介入治疗术前30 min肌注胃复安和安定。观察2组患者术后的恶心、呕吐等不良反应。结果盐酸格拉司琼组的止吐疗效明显高于对照组,2组比较有显著性差异(P<0.05);治疗组其他不良反应发生次数明显少于对照组。结论盐酸格拉司琼对介入化疗栓塞术患者是有效的止吐药物,值得临床推广应用。Objective To evaluate the prophylactic efficacy of granisetron on vomiting caused by TACE. Methods 60 Patients were randomly divided into two groups to receive either granisetron via liver artery injection（n = 30） or metoclopramidum combined with diazepam as controls（n = 30）. The antiemetic efficacy were compared between the two groups for 5 consecutive days after TACE. Results The effective rate of granisetron group was significantly higher than that of the control group（P 〈 0.05）.Conclusion Granisetron is an effective antiemetic drug in controlling vomiting caused by TACE and should be advocated in clinical practice .

关 键 词：盐酸格拉司琼 肝肿瘤 介入治疗 呕吐 预防 

分 类 号：R735.7[医药卫生—肿瘤]