99mTc-P53和99mTc-N(NOEt)2在肺部包块显像方面的比较研究  

Clinical application of 99mTc-P53 SPECT and 99mTc-N(NOEt)2 imaging in diagnosis of lung lesion.

作　　者：李定彪[1] 杨鸿生[1] 曹剑鸣[2] 尹小川[1] 洪志鹏[1] 晁福[1] 太祥[1] 

机构地区：[1]昆明医学院第一附属医院胸外科,云南昆明650032 [2]昆明医学院第一附属医院核医学科,云南昆明650032

出　　处：《云南医药》2006年第2期104-109,共6页Medicine and Pharmacy of Yunnan

摘　　要：目的研究99mTc-P53和99mTc-N(NOEt)2显像对肺癌的诊断及鉴别诊断方面的临床价值。方法用99mTc-P53和99mTc-N(NOEt)2分别对44例有病理诊断的肺部包块的病人进行SPECT显像。结果肺癌99mTc-N(NOEt)2的早晚期T/N比值差异有显著性。为判断良恶性的标准,99mTc-P53诊断的敏感性、特异性及准确性分别为91%,55%和81%,而99mTc-N(NOEt)2诊断的敏感性、特异性及准确性分别为88%,64%和81%。肺炎性假瘤对99mTc-P53和99mTc-N(NOEt)2都有比较高的摄取,二者比较无统计学意义。断层显像要优于平面显像。肺癌的大小不是决定肺99mTc-P53和99mTc-N(NOEt)2是否被浓聚的必然因素。在肺癌显像方面,99mTc-P53和99mTc-N(NOEt)2SPECT无显著性差异,二者与肺癌的不同TNM分期也无显著性差异。结论99mTc-P53和99mTc-N(NOEt)2对肺癌的显像有着良好的敏感性,但都相对缺乏特异性。To evaluate the clinical value of 99roTe- P53 and 99mTe- N （NOEt） 2 imaging for the diagnosis of lung neoplasms. Methods The SPECT imagings were performed on 44 patients with pulmonary lesions. Results The senstitivity, specificity and ovemU accuracy of 99mTc- P53 imaging for the malignant leson was 91%, 55%, 81%, respectively. The senstitivity, specificity and overall accuracy of 99mTc - N （NOEt） 2 imaging for the malignant lesion was 88%, 64%, 81% .Them was no significant differanee in different histological entities of the lung carcinoma. The probability of 99mTc- P53 and 99mTc- N （NOEt） 2 uptake in the mass was not related to the mass size. Four of the nine benign lung lesions （4 cases of inflammatory pseudotumor） and 5 of the nine benign lung leisons （5 eases of inflammatory pseudotumor） showed uptake. But there was no significant differanee between 99mTe - P53 and 99mTe - N （NOEt） 2 imaging. Conclusions Both 99mTe - P53 and 99mTe - N （NOEt） 2 are highly sensitive in detecting malignant lesions, but they have ooor soeeifieity.

关 键 词：99mTc-P53显像 99mTc-N(NOEt)2显像 肺部包块 单光子发射型计算机断层显像 

分 类 号：R734.1[医药卫生—肿瘤]