五氯酚钠与二噁英对人外周血淋巴细胞的影响  

Infection of Lymphocyte from Human Peripheral Blood by Sodium Pentachlorophenate and Dioxins

作　　者：方征[1] 刘征涛[1] 李响[1] 王婉华[1] 李霁[1] 

机构地区：[1]中国环境科学研究院国家环境保护化学品生态效应与风险评估重点实验室,北京100012

出　　处：《环境科学研究》2006年第2期20-22,共3页Research of Environmental Sciences

基　　金：国家自然科学基金资助项目(40332033)

摘　　要：将五氯酚钠(Na-PCP)与二英(2,3,7,8-TCDD)作为受试物,观察了人外周血淋巴细胞的彗星率和微核率.结果显示:Na-PCP与二英各质量浓度组的彗星率与微核率均比阴性对照组有明显的增高(P<0.001),而且随着质量浓度的增加而增高,呈明显的剂量-效应关系;阴性对照组与助溶剂对照组没有明显差异(P>0.05);Na-PCP与二英(2,3,7,8-TCDD)会对人外周血淋巴细胞的DNA造成损伤,而且随着质量浓度的增加,其对DNA的损伤将更加严重;Na-PCP对人外周血淋巴细胞造成的损伤为联合毒性所致.The comet assay and micronucleus assay were determined for lymphocyte from human peripheral blood, which is infected by Na-PCP and dioxins （2,3,7,8-TCDD）. Results indicated that comet rate and micronucleus rate of lymphocyte for the exposed groups were significantly higher than the control groups （ P 〈 0.001 ）, and it has dose-effect relationship. The negative group is no different as compared with the flux groups （ P 〉 0.05）. The Na-PCP and dioxins （2,3,7,8-TCDD） can damage DNA of lymphocyte from human peripheral blood, and the damage will rise with the increase of their mass concentrations. The damage from Na-PCP was caused by united toxicity.

关 键 词：五氯酚钠 二噁英 彗星试验 微核试验 淋巴细胞 

分 类 号：X171.5[环境科学与工程—环境科学]