涎腺腺癌COX-2表达和肿瘤血管生成的研究  

Study of COX-2 expression and angiogenesis in salivary gland adenocarcinoma

作　　者：李晓光[1] 高慎强[2] 张晓红[2] 王延秀[2] 亓春花[3] 李宁[4] 

机构地区：[1]山东省泰安市中心医院口腔科,271000 [2]山东省泰安市中心医院麻醉科,271000 [3]山东省泰安市中心医院中心实验室,271000 [4]山东省泰安市中心医院病理科,271000

出　　处：《重庆医学》2006年第8期707-709,共3页Chongqing medicine

摘　　要：目的探讨环氧合酶-2(COX-2)表达和涎腺腺癌血管生成的关系。方法免疫组化检测涎腺腺癌COX-2、诱导型一氧化氮合酶(iNOS)、血管内皮生长因子(VEGF)表达,并测定肿瘤微血管密度(MVD)。结果涎腺腺癌COX-2表达与VEGF、iNOS表达密切相关(P<0.05)。涎腺腺癌COX-2表达阳性组和阴性组MVD差异有统计学意义(P<0.01)。结论涎腺腺癌COX-2表达和肿瘤血管生成有关,iNOS和VEGF可能参与COX-2对肿瘤血管生成的促进作用。Objective To explore the relationship between COX-2 expression and angiogenesis in salivary gland adenoeareinoma. Methods The COX-2 expression, iNOS and VEGF expression, MVD were evalulated by immunohistochemical method. Results There was significant difference of MVD between COX-2 postive salivary gland adenocarcinoma and negative ones（P〈0.01）. The expressions of COX-2 significantly positively correlated with iNOS, VEGF in salivary gland adenocarcinomas. Conclusion The present findings suggest that there is some link between COX-2 and angiogenesis in salivary gland adenocarcinoma, partly attributing to the effect of VEGF and iNOS.

关 键 词：涎腺腺癌 环氧合酶 血管生成 血管内皮生长因子 诱导型一氧化氮合酶 

分 类 号：R739.8[医药卫生—肿瘤]