小剂量泰素加草酸铂治疗晚期胃癌疗效分析  

Low dose toxal and oxaliplatin in treatment of advanced gastric cancer

作　　者：林学德[1] 黄沂[1] 张志锋[1] 蔡雄超[2] 陈强[2] 

机构地区：[1]福建医科大学附属第一医院化疗科,福州350005 [2]福建省肿瘤医院化疗科,福州350014

出　　处：《中国肿瘤临床与康复》2006年第2期131-133,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨小剂量泰素及草酸铂联合化疗对晚期胃癌患者的疗效及安全性。方法对入组的32例经病理证实的晚期胃癌患者予小剂量泰素+草酸铂化疗,泰素60 mg,静脉滴注,每周1次;草酸铂100 mg,静脉滴注,每2周1次。12周为一完整疗程,完成6周以上化疗的患者予评估疗效及副作用。结果32例患者中,无CR,PR 22例(68.8%),NC 2例(6.3%),PD 8例(25.0%)。4例患者(12.5%)出现恶心,16例(50.0%)Ⅰ度白细胞下降,14例(43.8%)Ⅰ度肝功异常,2例(6.3%)Ⅱ度肝功异常。无其他毒副作用。结论小剂量泰素加草酸铂是一种对晚期胃癌患者疗效好、安全性高的方案,尤其适合于一般状况较差者及老年患者,值得临床推广应用。Objective To evaluate the efficacy and safety of combined use of low dose of taxol and oxalipatin in treatment of advanced gastric cancer. Methods Thirty-two pathologically certified advanced gastric cancer patients were enrolled into the study. All were given Taxol 60mg ivgtt qw and oxaliplatin 100 mg,ivgtt,q2w, one complete course was 12 weeks. The efficacy and safety were evaluated after 6 weeks of chemotherapy. Results Among 32 patients, no CR was seen, 22 （68.8%） got PR, 2 （6.3%） got NC and 8 （ 25.0 % ） got PD. Four patients （ 12.5 % ） had nausea, 16 （ 50.0 % ） had grade- Ⅰ leucopenia, 2 （ 6.3 % ） had grade- Ⅱ leucopenia, 14 （43.8 % ） had grade- Ⅰ hepatic dysfunction and 2 （6.3 % ） had grade- Ⅱ hepatic dysfunction. No other side effects occurred. Conclusion Combined use of low dose of taxol and oxaliplatin is a kind of effective and safe regimen for the chemotherapy of advanced gastric cancer patients, especially suitable for those with poor performance status and elderly patients. This regimen is worthy of using widely in clinic.

关 键 词：胃肿瘤/化学疗法 泰素 草酸铂 

分 类 号：R735.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]