培养的人胚胸腺和脾组织移植术对肿瘤患者免疫功能的影响  

Effect of Transplantation of Cdtured Fetal Thymus and Spleen on ImmunologicFunctions in Cancer Patients

作　　者：丁承恩 颜亭祥[1] 范文同[1] 欧阳贵廷 付庆元[1] 张亚军[1] 靳传荣 高瑞香[1] 陈伯元[1] 叶宇钦 

机构地区：[1]济南市第一人民医院临床免疫中心,济南市第一人民医院外科

出　　处：《齐鲁肿瘤杂志》1996年第1期36-37,共2页

摘　　要：本文应用培养的人胚胸腺和脾组织移植术治疗３６例肿瘤患者并设立２０例对照组两组患者均用常规疗法，观察组加用移植术，于移植前和移植后检测免疫功能。结果发现，观察组移植后较移植前细胞免疫明显增高（Ｅ－ＲＦＣ，ａ－ＲＦＣ，ＣＤ３，ＣＤ４，ＣＤ４／ＣＤ８，均Ｐ＜０．０１），体液免疫指标亦相应增高。观察组移植后与对照组相比其免疫功能亦明显升高。表明人胚胸腺和脾组织移植术可以改善肿瘤患者的免疫功能并间接证明移植物能存活。本组病例移植后无明显宿主抗移植物反应和移植物抗宿主反应。Effect of transplantation of cultured fetal thymus and spleen of immunologic functions was studied on 36 cancerpatients with 20 cancer patients as control group. Routine chemotherapy was given to all patients and irnmunologic functions weremeasured before and after transplantation.Our study showed that the cell-mediated immunologic functions in observed group weresignificantly increased after transplantation(E-RFC,a-RFC, CD3,CD4/ CD4/CD8,P<0.01,respectively),so were some parame-ters of humoral immunity.The immunologic functions in observed group after transplantation were alsohgher than those in con-trol group. These results indicated that transplantation of cultured thymus and spleen could improve immunologic functions in pa-tients with malignant tumor and indirectly proved that the transplantants could survive in vivo.No obvious GVHR and HVGRwas noticed during the period of study.

关 键 词：肿瘤 胸腺 脾脏 移植术 免疫功能 

分 类 号：R730.56[医药卫生—肿瘤] R730.51[医药卫生—临床医学]