TLR4基因多态性与慢性胃炎幽门螺杆菌感染无相关性  

No association between Toll-like receptor-4 gene polymorphism and Helicobacter pylori infection in chronic gastritis

作　　者：华开罗[1] 夏冰[2] 李春[2] 郭秋莎[2] 

机构地区：[1]武汉大学医学院附属中山医院消化内科,湖北省武汉市430033 [2]武汉大学中南医院综合医疗科,湖北省武汉市430071

出　　处：《世界华人消化杂志》2006年第7期718-721,共4页World Chinese Journal of Digestology

摘　　要：目的:研究我国湖北汉族人群TLR4基因 Asp299Gly多态性与慢性浅表性胃炎及幽门螺杆(H pylori)感染的关系．方法:采用病例-对照研究和多聚酶链反应-限制性片段长度多态性(PCR-RFLP)方法,检测 115例慢性浅表性胃炎患者115例和正常对照者2644例的TLR4等位基因Asp299Gly基因型分布．结果:慢性浅表性胃炎患者的H pylori阳性率 89．6％,显著高于正常对照组61．7％(P<0．000 1, OR=5．319．95％CI:2．784-10．162)．在H pylori 感染相关性的慢性胃炎组和正常对照组中 TLR4基因Asp299Gly基因型所有个体均为 AA纯合子,未发现的突变型,其基因型、等位基因以及携带者频率总体分布无显著性差异．结论:TLR4基因Asp299Gly基因多态性与H pylori相性慢性胃炎无明显相关性．Aims： To study the distribution of Toll-like receptor-4 （TLR4） gene Asp299Gly poly-morphism and to define association between TLR4 genotype and Helicobacter Pylori asso-ciated chronic gastritis in Han Chinese of Hubei province. Methods： One hundred and fifteen patients with chronic superficial gastritis and 264 healthy controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） method for TLR4 gene Asp299Gly polymorphism. Meanwhile, H pylori infection was also detected in all the individuals. Results： The rate of H pylori infection was 89.6% in patients with chronic superficial gastritis, and 61.7% in the healthy controls, and there was significant difference between them （P 〈 0.000 1, OR = 5.319, 95% CI： 2.784-10.162）. All the individuals had the same TLR4 Asp299Gly genotypes （AA）. The distributions of the genotypes and allele frequencies of TLR4 Asp299Gly were not significantly different between gastritis patients and healthy controls. Conclusion： There is no marked correlation between TLR4 Asp299Gly polymorphism and H pylori associated chronic gastritis in Han Chinese of Hubei province.

关 键 词：TOLL样受体4 幽门螺杆菌 基因多态性 慢性胃炎 

分 类 号：R573.3[医药卫生—消化系统]