双侧牙槽嵴裂动物模型的建立及对上颌骨生长发育的影响  

Effect of surgically induced bilateral cleft alveolar on maxillary growth in dogs

作　　者：欧新荣[1] 翦新春[1] 

机构地区：[1]中南大学湘雅医院口腔科

出　　处：《中南大学学报（医学版）》2006年第2期215-217,共3页Journal of Central South University ：Medical Science

基　　金：湖南省自然科学基金(05JJ30171)

摘　　要：目的:建立双侧牙槽嵴裂大动物模型,研究其对上颌骨发育的影响。方法:选用8只1 2周龄的同窝实验犬,随机分成正常对照组和实验动物模型组,对实验组的动物采用外科手术的方法建立裂隙程度一致的双侧上颌牙槽嵴裂,术后1 2周处死动物,通过实体标本、三维CT等对两组动物行头颅测量。结果:实验模型组牙槽嵴裂裂隙为(1 0.8 1±0.4 1)mm,其上颌骨长度、前部宽度和前部高度较正常对照组明显缩小(P<0.0 5)。结论:牙槽嵴裂对上颌骨生长发育具有一定的影响。Objective To establish an animal model of bilateral alveolar cleft and to determine the effect of cleft on maxillary growth. Methods Eight dogs （ 12 weeks old ） were divided into unoperated control groups （ n = 4 ） and the model group （ n = 4 ） . The model dogs were operated to establish a bilateral alveolar cleft. All the dogs were killed and the craniofacial morphology on clean group （P 〈0. 05 ）. Conclusion The alveolar cleft plays an important role in the maxillary aberration.

关 键 词：牙槽嵴裂模型 上颌骨 生长发育 犬 

分 类 号：R-332[医药卫生]