复方薤白胶囊对慢性支气管炎大鼠血小板活化因子及一氧化氮的影响  

The effect of the compound Xiebai capsule on platelet activate factor and nitrous oxide in rats with chronic bronchitis

作　　者：冷报浪[1] 奚肇庆[2] 曹世宏[2] 

机构地区：[1]浙江省杭州市第三人民医院,浙江杭州310009 [2]南京中医药大学附属医院,江苏南京210029

出　　处：《现代中西医结合杂志》2006年第10期1293-1294,1299,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察复方薤白胶囊对慢性支气管炎大鼠的治疗作用及对血小板活化因子(PAF)、一氧化氮(NO)的影响。方法采用SO2熏吸法复制大鼠慢性支气管炎模型,观察分别应用复方薤白胶囊和地塞米松治疗后症状、PAF及NO浓度、肺泡灌洗液中细胞含量变化。结果治疗后,与模型组比较,复方薤白胶囊组和地塞米松组动物一般情况改善、血浆PAF和血清NO浓度下降,BALF中中性粒细胞和肺巨噬细胞含量减少,其中减少BALF中中性粒细胞的作用,复方薤白胶囊组优于地塞米松组(P<0.01)。结论复方薤白胶囊对慢性支气管炎大鼠有明显的治疗作用,降低血浆PAF和血清NO浓度是其重要的治疗机制之一,这一作用机制可能与减少炎症细胞在气道过度聚集有关。Objective It is to observe the treatment function of compound Xiebai capsule on chronic bronchitis and the effect on platelet activate factor （PAF） and nitrous oxide （NO）. Methods The models of rats with chronic bronchitis made by SO2 fumigation, were treated with compound Xiebai capsule Dexamethasone （DXM） respectively, and the changes of the symptoms, the concentration of PAF and NO, the content of cells in pulmonary alveolus irrigating solution were observed after the treatment. Results Compared with model group after treatment, general state of health was improved, the concentration of PAF and NO were decreased, neutrophils and PDNs in pulmonary alveolus irrigating solution reduced in compound Xiebai capsule group and DMX group. Moreover, the neutrophils in pulmonary alveolus irrigating solution reduced more in compound capsule group than those in DMX group （P 〈 0.01 ）. Conclusion Compound Xiebai capsule has an obvious curative effect on chronic bronchitis in rats. It is one of the important treatment mechanisms to reduce plasma concentration of PAF and serum NO, which maybe is related to the improvement of inflammation cells over-collecting in the airway.

关 键 词：复方薤白胶囊 慢性支气管炎 血小板活化因子 一氧化氮 

分 类 号：R-332[医药卫生]