端基为肝靶向基团的聚谷氨酸苄酯的合成及表征  

Syntheses and Characterization of Poly(γ-benzyl-L-glutamate) Containing Liver Targeting Group in Main Chain

作　　者：查瑞涛[1] 杜田[1] 袁直[1] 

机构地区：[1]功能高分子材料教育部重点实验室南开大学高分子化学研究所,天津300071

出　　处：《高等学校化学学报》2006年第5期885-887,共3页Chemical Journal of Chinese Universities

基　　金：教育部天津大学-南开大学科技合作基金资助

摘　　要：Started from the liver targeting compounds（glycyrrhizin,glycyrrhetinicacid,bile acid）,six（amine-terminated） compounds were prepared via two-step reactions.The NMR experiments provided the direct evidence of the existence of amide.The polymers were synthesized by polymerizing of BLG-NCA initiated by each of six amine-terminated compounds.The liver targeting group was introduced to the main chain of the polymer.The molecular weight of the resultant polymers was adjusted by changing the molar ratio of monomer BLG-NCA to initiator.The product structure was characterized by GPC,FTIR and（）1H NMR.The results demonstrate that amine-terminated compounds containing liver targeting group could initiate the polymerization of BLG-NCA.Started from the liver amine-terminated compounds were p targeting compounds （ glycyrrhizin, glycyrrhetinicacid, bile acid ）, six repared via two-step reactions. The NMR experiments provided the direct evidence of the existence of amide. The polymers were synthesized by polymerizing of BLG-NCA initiated by each of six amine-terminated compounds. The liver targeting group was introduced to the main chain of the polymer. The molecular weight of the resultant polymers was adjusted by changing the molar ratio of monomer BLG-NCA to initiator. The product structure was characterized by GPC, FTIR and ^1H NMR. The results demonstrate that amine-terminated compounds containing liver targeting group could initiate the polymerization of BLG-NCA.

关 键 词：肝靶向 甘草酸 甘草次酸 胆酸 聚谷氨酸苄酯 

分 类 号：Q592.1[生物学—生物化学] Q592.2