康莱特增强中晚期食管癌患者对放疗的耐受性  

Kanglaite improve radiation tolerance of advanced esophagus cancer patients

作　　者：刘苗生[1] 王崇宇[2] 

机构地区：[1]长治医学院附属和平医院放疗科,山西长治046000 [2]浙江海洋学院医学院,浙江舟山316000

出　　处：《现代肿瘤医学》2006年第5期566-567,共2页Journal of Modern Oncology

摘　　要：目的观察放疗联合应用康莱特对中晚期食管癌患者耐受情况的影响。方法回顾31例康莱特联合放疗治疗中晚期食管癌患者白细胞计数、KPS评分、治疗间断时间、疗效,并与对照组31例进行比较分析。结果放疗后治疗组的白细胞水平和KPS评分明显高于对照组;康莱特治疗组治疗间断时间为1.43±0.48天,显著低于对照组的3.24±1.02天,P<0.05;治疗组的1年、2年生存率为77.4%和53.3%,比对照组的58.1%和35.5%稍高,但没有显著性差异。结论联合应用康莱特可以提高中晚期食管癌放疗患者的耐受性,减少治疗间断时间。Objective：To investigate the effect of Kanglaite on radiation tolerance of advanced esophagus cancer. Methods：Thirtyone cases of advanced esophagus cancer treated by Kanglaite combined with radiotherapy （Kh - group） and matched control（C- group） were surveyed. The white blood cell count , KPS,break time of treatment and survival rate of two groups were analyzed retrospectively. Results： 1 - year and 2 - year survival rates in Klt - group （77.4% and 53.3% ）were higher than that in C -group（58.1% and 35.5% ）, but which showed no statistically significant difference,P 〉0.05 ;the white blood cell count , KPS in Klt -group were significantly higher than that in C - group,P 〈0.05 ;the break time of treatment in Klt - group was significantly lower than that in C - group, P 〈 0.01. Conclusion： Kanglaite can improve radiation tolerance of advanced esophagus cancer.

关 键 词：康莱特 食管癌 放射耐受性 

分 类 号：R730.53[医药卫生—肿瘤]