结直肠癌术后肝转移相关因素分析  

The relative parameters of liver metastasis of colorectal carcinoma after surgery

作　　者：周立生[1] 李大鹏[1] 王斌[1] 李继坤[1] 

机构地区：[1]交通大学附属第一人民医院普外科,上海200080

出　　处：《中国癌症杂志》2006年第5期394-395,共2页China Oncology

摘　　要：背景与目的:结直肠癌肝转移作为最常见的转移途径之一,尚缺乏有效的预测、评估指标,本文即探讨结直肠癌术后肝转移与其临床病理因素的关系。方法:比较术后2年发生肝转移107例Dukes B或C期结直肠癌患者与术后2年无肝转移100例患者的血清CEA水平、分析病理切片分化级别、转移淋巴结、淋巴管侵袭以及静脉侵袭的情况。结果:发生肝转移患者远距离淋巴结转移、淋巴管侵袭及镜下静脉侵袭发生率升高,术后CEA持续升高,与无肝转移组比较有显著性差异(P<0.05)。结论:结直肠癌术中未发现肝转移但有远距离淋巴结转移、淋巴管侵袭或镜下静脉侵袭以及术后CEA持续升高,预示发生肝转移的危险性增加。Background and purpose： Liver is one of the most common metastatic sites in colorectal carcinoma, but there is no biomarker that could be used to predict and evaluate the possibility of metastases in the liver. Our study is aiming to investigate the relative parameters of liver metastasis of colorectal carcinoma after surgery. Methods： Several factors, including serum CEA level, lymph node metastasis , vessel and lymph vessel invasion, pathologic character of primary tumor, were used for analysis, the data was collected from either patients of eoloreetal carcinoma with （ 107 cases） and without（ 100 cases） hepatic metastasis in 2 years. All of the patients received surgery. Results： Patients with hepatic metastasis had significantly higher positive rates in terms of remote lymph node metastasis, vessel and lymph vessel invasion, respectively （P 〈 0.05）. The level of serum CEA was increased after surgery compared to the patients without hepatic metastasis （P 〈 0.05）. Conclusions： The patients with colorectal carcinoma having remote lymph node metastasis, vessel and lymph vessel invasion and plasma CEA level after surgery may indicate a higher risk of hepatic metastasis.

关 键 词：结直肠癌 肝转移 病理 CEA 

分 类 号：R735.35[医药卫生—肿瘤] R73-37[医药卫生—临床医学]