新型抑癌基因RASSF1与胃癌的关系  

The relationship between new suppressor gene RASSF1 and gastric-carcinoma

作　　者：李学彦[1] 傅宝玉[2] 

机构地区：[1]沈阳军区总医院肿瘤科,辽宁沈阳110016 [2]中国医科大学附属一院消化科,辽宁沈阳110003

出　　处：《中国癌症杂志》2006年第5期396-398,共3页China Oncology

摘　　要：新近发现的RASSF1A基因位于染色体3p21.3区,是一种新型侯选肿瘤抑制基因,多项研究表明它可参与细胞凋亡和多种恶性肿瘤的发生。在多种肿瘤中失活。该基因的失活与其启动子区甲基化和杂合子缺失有关。另外发现一些病毒的感染可影响其甲基化状态。RASSF1 , a putative tumor suppressor gene identified at 3p21.3 has been frequently observed. Many reports suggested that those was no RASSF1 expression or was at abnormally low level in many carcinomas. It is possible that aberrant DNA methylation and loss of heterozygusity might be involved in the loss of RASSF1 expression. Other results demonstrate a relationship between EBV infection and aberrant methylatiun.

关 键 词：RASSF1A 甲基化 胃癌 抑癌基因 

分 类 号：R735.2[医药卫生—肿瘤]