草酸铂加CF/5-FU48小时持续静脉滴注双周疗法治疗晚期胃癌83例疗效分析  

Clinical study of the curative effect of oxaliplatin plus CF/5-FU in advanced gastric cancerby biweekly therapy of 48-hour continuous intravenous infusion

作　　者：熊萍[1] 连捷[1] 余小清[1] 

机构地区：[1]广东省农垦中心医院,广东湛江524002

出　　处：《现代医药卫生》2006年第10期1436-1437,共2页Journal of Modern Medicine & Health

摘　　要：目的:观察草酸铂(L-OHP)与CF/5-FU48小时持续静脉滴注双周疗法治疗晚期胃癌疗效及不良反应。方法:经病理证实的83例晚期胃癌患者随机分为治疗组和对照组。治疗方案:治疗组用L-OHP加CF/5-FU;对照组用VP16加CF/5-FU,两组均2周为1周期。结果:经过2个周期化疗,治疗组有效率(CR+PR)57.5%比对照组有效率34.9%高,两组比较差异有统计学意义(#2=4.2702,P=0.0388)。治疗中无疾病进展及治疗相关死亡,胃肠道反应及骨髓抑制均为轻中度,无显著性差异。神经毒性治疗组明显低于对照组,两组差异有统计学意义(P<0.01)。结论:L-OHP加CF/5-FU48小时持续静脉滴注双周疗法治疗晚期胃癌疗效高,不良反应轻,有希望成为最有效的治疗方案。Objective：To observe the anti-tumor effect and safety of oxaliplatin combined with CF/5-FU in the treatment of advanced gastric cancer by biweekly therapy of 48-bour continuous intravenous infusion.Methods：83 patients with advanced gastric cancer were randomly divided into treatment group and control group. Treatment group was treated with oxaliplatin plus CF/5-FU added into the chemotherapy pump by 48-hour continuous intravenous infusion,while Control group was treated with VP16 plus CF/5-FU in the same method as treatment group,a cycle was two weeks.AN enrolled patients received two cycles of treatment.Results：The effective rate was 57.5% in the treatment group and 34.9% in the control group,with a significant difference between them （x^2=4.2902,P=0.0388）,There was no significant difference in bone marrow suppression,nausea and vomiting between two groups.The rate of peripheral neurilemmitis response had significant difference between two groups （P〈0.001）. Conclusion：Oxaliplatin plus CF/5-FU by biweekly therapy of 48-hour continuous infusion is very effective for the treatment of advanced gastric cancer with mild toxicity, which can be practiced safety.

关 键 词：L-OHP CF/5-FU 晚期胃癌 持续静脉滴注 双周疗法 草酸铂 

分 类 号：R735.2[医药卫生—肿瘤]