精神分裂症患者的脑功能显像与神经心理测验的相关研究  

The Relationship between Cerebral Blood Flow and Neuropsychological Functioning in Schizophrenia.

作　　者：李星宝[1] 戴郑生[1] 田成慧[1] 栾习云[1] 唐济生[1] 赵贵芳[1] 王善信[1] 宋绳禹[1] 吴志兴[2] 郭川流[2] 

机构地区：[1]山东省精神卫生中心 [2]山东省立医院核医学科

出　　处：《中国临床心理学杂志》1996年第3期135-138,共4页Chinese Journal of Clinical Psychology

摘　　要：本研究应用单光子发射断层摄影术（ＳＰＥＣＴ）、ＨＲ成套神经心理测验（成人）修订本［ＨＲＢ（Ａ）－ＲＣ］和修订韦氏记忆测验（ＷＭＳ－ＲＣ）对３２例住院精神分裂症患者的脑功能改变及脑功能显像与神经心理测验之关系进行探讨。结果显示，精神分裂症患者存在额叶、颞叶和基底节的脑血灌流量降低，同时表现程度不同的神经心理功能损害，此改变在阴性症状和阳性症状的病人间无差异。脑血灌流量降低与损伤指数（ＤＱ）和记忆商数（ＭＱ）未见明显关系。相关分析表明，ＤＱ与ＴＥＳＳ评分呈显著正相关（ｒ＝０．３６，Ｐ＜０．０５）；ＭＱ与住院次数（ｒ＝－０．４２，Ｐ＜０．０５）、ＢＰＲＳ评分（ｒ＝－０．５６，Ｐ＜０．０１）、ＳＡＰＳ评分（ｒ＝－０．３９，Ｐ＜０．０５）和ＳＡＮ评分（ｒ＝－０．３７，Ｐ＜０．０５）呈显著负相关，与ＧＡＳ评分（ｒ＝０．５３，Ｐ＜０．To explore the relationship between cerebral blood flow and neuropsychological function, 32 schizophrenic patients were investigated with single photon emission computed tomography(SPECT), HRB(A)-RC and WMS-RC. Results showed that regional cerebral blood flow decreased significantly in the frontal lobes, temporal lobes and basal ganglia. DQ increased and MQ decreased. DQ was positively correlated with TESS score. Although MQ was positively correlated with GAS score, it was negatively correlated with the number of hospitalization and the scores of BPRS, SANS and SAPS.

关 键 词：精神分裂症 脑功能显像 神经心理测验 

分 类 号：R749.3[医药卫生—神经病学与精神病学]