重症肝病与全身炎症反应综合征  

Severe liver diseases and systemic inflammatory response syndrome

作　　者：刘毅[1] 任红[1] 郭树华[1] 

机构地区：[1]重庆医科大学附属第二医院感染科,400010

出　　处：《国际流行病学传染病学杂志》2006年第2期136-138,共3页International Journal of Epidemiology and Infectious Disease

摘　　要：全身炎症反应综合征(SIRS)是各种致病因素触发机体免疫产生的过度炎症、凝血及削弱的纤溶反应的一种临床过程,其中感染引起的全身炎症反应又称为脓毒症(sepsis),是导致危重病患者多器官功能不全(MODS)和死亡的重要原因。肝硬化、肝衰竭等重症肝病患者感染率高,可诱发肝性脑病等严重并发症而降低患者生存率。近年发现SIRS/sepsis参与了病情的演进;针对炎症发生发展各个环节,及时有效的干预治疗可望延缓病情恶化。Systemic inflammatory response syndrome （SIRS） is the clinical manifestation of inflammation and therefor the product of complex interactions among inflammation, coagulation and impaired fibrinolysis that occur simultaneously in response to an immune trigger, and sepsis when associated with a proven or suspected microbial event. Both SIRS and sepsis compromise a continuum of organ injury and death in critical-ill patients. Since infection in patients with decompensated cirrhosis,acute and acute-on-chronic liver failure is common and SIRS/sepsis has been found to be important in the development of the complications such as hepatic encephalopathy recently, it is possible to postpone the deterioration of critical-ill patients by therapy targeting every step during the development of SIRS/sepsis.

关 键 词：肝硬化 肝衰竭 综合征 炎症 

分 类 号：R575[医药卫生—消化系统]