先兆子痫患者HLA-DQHLA-DPA1基因多态性分析  

Research on polymorphism of HLA-DQ, -DPA1 in patients with preeclampsia

作　　者：侯磊[1] 张曦[1] 张展[1] 贾莉婷[1] 熊平[2] 常彩虹[1] 王雪梅[1] 龚非力[2] 

机构地区：[1]郑州大学第三附属医院,河南郑州450052 [2]华中科技大学同济医学院免疫教研室,武汉430030

出　　处：《中国妇幼保健》2006年第9期1231-1234,共4页Maternal and Child Health Care of China

基　　金：河南省卫生厅专项基金资助;项目编号21764

摘　　要：目的:探讨人类白细胞抗原HLA-DQ、HLA-DPA1基因多态性与先兆子痫发病的关系。方法:采用序列特异性引物技术(PCR-SSP)对46例先兆子痫患者和105例正常孕妇及其新生儿进行HLA-DQA1、HLA-DQB1、HLA-DPA1等位基因分型,比较其基因频率。结果:所有标本共检出11种HLA-DQA1基因表型、16种HLA-DQB1基因表型,6种HLA-DPA1基因表型。先兆子痫患者HLA-DQB1*0301基因频率高于正常孕妇,差异有显著性(Pc=0·032,RR=2·43,AR=0·30),其余各基因表型频率两组比较差异均无显著性。结论:HLA-DQ81*0301基因可能是一种先兆子痫发病的易感基因。Objective： To explore the relationship between HLA - DQ or HLA - DPAI alleles and preeelampsia. Methods： The HLA- DQ and HLA -DPA1 typing were performed using sequence -specific amplification （PCR- SSP） in 46 patients and 105 healthy pregnant women and their newborns. Results： The HLA, DQB1 ＊ 0301 alleles frequency was higher in patients with preeclampsia （30. 43% ） than those in the tested group of healthy controls （16. 19% ） （Pc =0. 032, RR =2.43, AR =0. 30） . There were no signfieiant difference in the HLA- DQA1 and HLA -DPB1 alleles frequency between patients with preeclampsia and controls. No difference was found in HLA- DQ or HLA -DPBI maternal -fetal genetic sharing between the two groups. Conclusion： The presence of HIA -DQB1 ＊ 0301 alleles may increase the risk of preectampsia.

关 键 词：妊娠并发症 先兆子痫 抗原 等位基因 多态性 

分 类 号：R714.244[医药卫生—妇产科学]