抗α肿瘤坏死因子新靶点的进展  

New Research Targets of Anti-TNF alpha

作　　者：张红[1] 顾军[1] 

机构地区：[1]第二军医大学长海医院皮肤科,上海200433

出　　处：《国际皮肤性病学杂志》2006年第3期188-190,共3页International Journal of Dermatology and Venereology

基　　金：国家自然科学基金资助(30271197)

摘　　要：α肿瘤坏死因子是介导炎症反应和免疫反应的细胞因子,具有广泛的生物学活性。近年来,国内外抗α肿瘤坏死因子药物的研究进展迅速。从抑制α肿瘤坏死因子、肿瘤坏死因子前体生成、拮抗已经释放的肿瘤坏死因子作用方面简要介绍了目前研究的几个主要靶点及相关药物。Tumor necrosis factor-alpha （ TNF- α ） is a cytokine mediating inflammatory reaction and immune responses, and has various biological activities. Recently,the research on anti-TNF-α drugs has developed rapidly. This article reviews the main targets of the present research and correlated drugs inhibiting the production or precursors of TNF- α and antagonizing released TNF.

关 键 词：Α肿瘤坏死因子 抗α肿瘤坏死因子 靶点 

分 类 号：R363[医药卫生—病理学]