纤维素对大鼠结肠癌前期病变形成的影响  

The effect of cellulose on the formation of pre-cancer lesion of colon in rat

作　　者：陈尔真[1] 燕敏 曹伟新[1] 张明钧 高月锦 

机构地区：[1]上海交通大学医学院附属瑞金医院临床营养科,200025 [2]上海市消化外科研究所

出　　处：《中华消化杂志》2006年第3期176-179,共4页Chinese Journal of Digestion

摘　　要：目的探讨纤维素对大鼠结肠癌前期病变畸变隐窝病灶(ACF)形成的影响。方法 48 只雄性Wister大鼠经适应性喂养1周后均分为4组,A、B组给予标准鼠食,C、D组则给予含10％纤维素的鼠食;同时B、D组连续10周每周1次腹腔内注射二甲基肼(每次20 mg／kg),而A、C组则给予等量生理盐水;喂养至第12周处死大鼠,观察大鼠结肠ACF的变化。结果各组大鼠体重增加及结肠长度差异无统计学意义,腹腔内脏器未见明显异常。C、D组大鼠盲肠内容物重量显著高于A、B组,但各组近、远端结肠内容物重量差异无统计学意义,D组大鼠各肠段ACF总数及病灶≥4个隐窝的ACF数均显著低于B组。结论纤维素能抑制大鼠结肠癌前期病变的形成。Objectives To investigate the effect of cellulose on the formation of aberrant crypt loci （ACF） in rats colon. Methods Forty-eight Wister male rats were randomized into 4 groups after oneweek acclimatization, The rats in group B and D were given 1, 2-dimethylhydrazine （20 mg/kg） intraabdominally once a week until 10 weeks, whereas the rats in group A and C with the same volume of norreal saline. The rats in group A and B were fed with standard forage whereas the rats in group C and D with forage containing 10% cellulose. At the 12th week, all the rats were sacrificed to examine the ACF in their colon. Results There were no significant differences in rat＇s weight gain and the length of colon among study groups, There were no abnormal lesions in viscera of all rats. The content of cecum in rats fed with cellulose was higher than that with standard forage, but there was no significant difference between the content of distal and proximal colon in all groups. The total number of ACF and the lesions that contained more than 4 crypts in colon of group D rats was significantly fewer than that of group B. Conclusions The cellulose could inhibit the formation of pre-cancerous lesion in colon of rats.

关 键 词：纤维素 结肠癌 癌前期病变 畸变隐窝病灶 

分 类 号：R735.35[医药卫生—肿瘤]