SSRIs/西酞普兰对卒中后认知功能障碍的影响  

Influence of SSRIs(selective serotonin reuptake inhibitors)/citalopramon cognitive impairment in patients with stroke

作　　者：陈长宇[1] 陈康宁[1] 柳春雨[1] 段炜[1] 

机构地区：[1]第三军医大学西南医院神经内科,重庆400038

出　　处：《重庆医科大学学报》2006年第2期240-242,252,共4页Journal of Chongqing Medical University

摘　　要：目的:观察选择性5-HT再摄取抑制剂类药物西酞普兰对患者卒中后认知功能障碍的影响。方法:所有患者为第三军医大学附属西南医院神经内科住院病人,应用简易精神状态量表筛选卒中后认知功能障碍的患者40例,随机分为治疗和对照组,在常规治疗的同时治疗组加西酞普兰片,为每天早餐后口服20mg,连用3个月。在治疗前和治疗后1月、3月使用简易精神状态量表,汉密尔顿抑郁量表,美国国立卫生院卒中量表,Barthel指数评定患者的功能。结果:治疗后治疗组患者的认知功能改善明显优于对照组(19.35±2.85,21.55±3.24,P<0.05)。结论:西酞普兰能改善患者卒中后认知功能障碍。Objective： To investigate the effect of early treatment with SSRIs/Citalopram on cognitive impairment in patients with stroke. Methods： A total of forty patients with cognitive impairment following stroke,in the Department of Neurology, Southwest Hospital of the Third Military Medical University, selected by the Mini-Mental State Examination, were randomly divided into treatment group and control group. All the patients received routine treatment, besides Citalopram were given to those in the treatment group. 20mg Citalopram Hydrobromide Tablets would be given after breakfast everyday for 3 mouths. Patients in both groups were investigated with the Mini-Mental State Examination, Hamilton Rating Scale for Depression, National Institute of Health Stroke Scale and Barthel Index to examine the functions before and 1 and 3months after treatment respectively. Result： The improvement of cognitive function of patients in the treatment group was obviously superior to those in the control group （ 19.35 ± 2.85,21.55 ± 3.24, P〈 0.05 ）. Conclusion： Citalopram can promote the recovery of cognitive impairment in patients with stroke.

关 键 词：选择性5-HT再摄取抑制剂 西酞普兰 认知功能障碍 

分 类 号：R743.3[医药卫生—神经病学与精神病学]