Regioselective Ring-opening Reaction of 1,2-Epoxides with Arylselenol under Solvent-free Conditions and Application to the Synthesis of 1,3-Oxazolidin-2-ones  

作　　者：杨明华 袁朝英 潘毅 朱成建 

机构地区：[1]State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, China [2]Department of Chemistry, Lishui College, Lishui, Zhejiang 323000, China

出　　处：《Chinese Journal of Chemistry》2006年第5期669-673,共5页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos. 20472028, 20332050） and Education Commission of Zhejiang Province.

摘　　要：Regioselective ring-opening reactions of 1,2-epoxides with ArSeH catalyzed by Ti（O^tPr）4 under solvent-free conditions were investigated. A variety of β-hydroxyselenides were obtained in excellent yields of 90%-97% and regioselectivities by a simple, atom economic and environment-friendly procedure. Several N-tosyl- 1,3-oxazolidin-2-ones were prepared starting from the corresponding 1,2-epoxides and ArSeH by a one-pot three-step procedure.Regioselective ring-opening reactions of 1,2-epoxides with ArSeH catalyzed by Ti（O^tPr）4 under solvent-free conditions were investigated. A variety of β-hydroxyselenides were obtained in excellent yields of 90%-97% and regioselectivities by a simple, atom economic and environment-friendly procedure. Several N-tosyl- 1,3-oxazolidin-2-ones were prepared starting from the corresponding 1,2-epoxides and ArSeH by a one-pot three-step procedure.

关 键 词：EPOXIDE arylselenol solvent-free reaction titanium isopropoxide 1 3-oxazolidin-2-one 

分 类 号：O626[理学—有机化学] O621.25[理学—化学]