瘤内注射纳科思联合放疗的方法探讨  

Modality and effect of combining radiotherapy with intratumorous rmhTNF injection

作　　者：钟立松[1] 张仟仕[1] 

机构地区：[1]德阳市人民医院肿瘤科,四川德阳618000

出　　处：《西部医学》2006年第3期295-296,共2页Medical Journal of West China

摘　　要：目的探讨浅表肿块内注射纳科思(TNF-α变构体)联合放疗的方法和安全性。方法29例恶性肿瘤浅表肿块的治疗方法分为甲、乙两组,甲组16例,先给予肿块放疗(DT 16GY/8F),然后瘤内注射纳科思;乙组13例,瘤内注射纳科思同时联合放疗。结果甲、乙两组近期疗效差异无统计学意义(P>0.05);甲组较乙组的不良反应低(P<0.05)。结论在纳科思联合放疗浅表恶性肿块时,先给予肿块放疗,再行瘤内注射纳科思(TNF-α变构体)联合放疗的方法较好,不良反应较低,安全性较高。Objective To investigate the method and security of t he combining radiotherapy with injecting rmhTNF（TNF-αmutant） into shallow tumors. Methods Twenty-nine patients who suffered from malignant tumors were divided into two groups. In Group A, 16 patients underwent the radiotherapy of DT16GY/SF, then they were treated by injecting rmhTNF into the tumors. In Group B, 13 patients were treated by radiotherapy and intratumorous rmhTNF injection at the same time. Results Statistically there was no significant difference in the curative effect in short term （P〉0. 05） . The patients in Group A had lower side-effects than those of Group B （P〈0. 05）. Conclusion In the process of the treatment, the radiotherapy is preferably administrated first and followed by intratumorous rmhTNF injection for this modality has been corroborated to be more safe and have less side effects.

关 键 词：纳科思 恶性肿瘤 肿块内注射 联合放疗 

分 类 号：R730.5[医药卫生—肿瘤]