西酞普兰与阿米替林治疗抑郁症的对照研究  

Comparison of citalopram and amitriptyline in treatment of depression

作　　者：付蓉[1] 朱春红[1] 

机构地区：[1]天津市安康医院,天津300240

出　　处：《武警医学》2006年第4期250-251,共2页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的评估西酞普兰与阿米替林治疗抑郁症的临床疗效和不良反应。方法将68例抑郁症患者随机分为2组,分别为西酞普兰治疗组和阿米替林对照组,疗程6周,以Hamilton抑郁量表(HAMD)17项版本评分及治疗中需处理的不良反应症状量表(TESS)评定疗效和安全性。结果2组治疗结束时的HAMD评分减分率比较差异无统计学意义(P>0.05),但不良反应西酞普兰组优于阿米替林组。结论西酞普兰治疗抑郁症安全有效,可作为一线药物使用。Objective To evaluate the clinical response and adverse reaction of eitalopram and amitriptyline in treating depression. Methods Sixty - eight patients with depression were randomly divided into two groups, citalopram group and amitriptyline group, with a treatment of 6 weeks. The response and safety were assessed with Hamiltm rating scale for depression （HAMD） and TESS. Results There was no significant difference in HAMD between the two groups （ P 〉 0.05）, but citalopram group is better than amitriptyhne group in rating scale of sideeffects. Conclusions Citalopram is efficacious and safe in treating depression, so it can be used as a preferred remedy.

关 键 词：西酞普兰 阿米替林 抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R971.43[医药卫生—临床医学]