血管内皮细胞生长因子家族的研究现状  

The Research Status of Vascular Endothelial Growth Factor Family

作　　者：王明松[1] 邹良建[1] 

机构地区：[1]第二军医大学附属长海医院胸心外科,上海200433

出　　处：《医学综述》2006年第9期534-536,共3页Medical Recapitulate

摘　　要：血管内皮细胞生长因子(VEGF)家族成员,VEGF-B、胎盘生长因子(PIGF)、VEGF-C及VEGF-D和它们的受体VEGFR-1、-2与-3为研究脉管系统的发育提供了工具,也为缺血性心脏病及癌症的治疗提供了研究工具。尽管在血管新生和人的血管系统生理学中的作用已有较多研究,但到目前为止,VEGF家族在淋巴管系统中的作用研究较少。兹将VEGF家族在血管新生及淋巴管新生研究方面的最新进展,简要综述。The discovery of the vascular endothelial growth factor （VEGF） family including VEGF, VEGF-B, placental growth factor （PIGF）, VEGF-C, and VEGF-D as well as their receptors VEGFR-1, -2 and -3 has provided a tool not only to study the development of vascular system, but also to treat the ischemic heart disease and cancer. While many studies have addressed its role in angiogenesis and physiology of human blood vasculature, little is known about its role in lymphatic vascular system. In this review, we will discuss the recent advancement of VEGF family in the genesis of blood vessel and lymph vessel.

关 键 词：缺血性心脏病 肿瘤 血管内皮细胞生长因子 血管新生 淋巴管新生 

分 类 号：R730.2[医药卫生—肿瘤]