氟代碳核苷类化合物的合成研究──N－烷基－5－甲酰胺基－1，2，4－氧杂二唑基－3－（4＇－脱氧－4＇－氟－β－L－吡喃型阿拉伯糖）的合成  

Studies on the Synthesis of Fluorinated C-Nucleosides──Synthesis of N-Alkyl 3-(4'-deoxy-4'-fluoro-β-L-arabinopyranosyl)1,2,4-oxadiazole-5-carboxamides

作　　者：程华[1] 马灵台[1] 张礼和[1] 

机构地区：[1]北京医科大学药学院

出　　处：《高等学校化学学报》1996年第7期1078-1082,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金

摘　　要：报道了Ｎ－烷基５－甲酰胺基－１，２，４－氧杂二唑基－３－β－Ｄ－吡喃木糖用二乙胺基三氟化硫选择性氟化，得到相应的Ｎ－烷基－５－甲酰胺基－１，２，４－氧杂二唑基－３－（４＇－脱氧－４＇－氟－β－Ｌ－吡喃型阿拉伯糖）；并用光谱分析确证了它们的构型及在溶液中的构象。N-Alkyl-3(4'-deoxy-4'-fluoro-β-L-arabinopyranosyl)-1,2,4-oxadiazole-5-carboxamids were synthesized from the corresponding N-alkl 3-β-D-xylopyranosyl-1,2,4-oxadiazole-5-carboxamides which were selectively fluorinated at 4'-position of sugar moiety with diethylaminosulfur trifluoride(DAST).The configuration and conformation of these new Cnucleoside derivatives were identified by ￣1H NMR,￣(13)C NMR,￣(19)F NMR,￣1H-￣1H COSY and MS.

关 键 词：氧杂二唑 选择性氟化 碳核苷 

分 类 号：O629.74[理学—有机化学]