上皮性卵巢癌中Skp2蛋白的表达及临床意义  

Clinical Significance and Expression of Skp2 Protein in Ovarian Epithelial Tumors

作　　者：刘云春[1] 魏荣英[1] 李建平[1] 

机构地区：[1]河北北方学院附属第一医院妇产科,河北张家口075000

出　　处：《河北北方学院学报（医学版）》2006年第2期24-26,共3页Journal of Hebei North University:Medical Edition

摘　　要：目的:探讨Skp2蛋白表达与上皮性卵巢癌发生、发展及预后评价的意义。方法:采用免疫组化法检测15例卵巢上皮性良性肿瘤、10例卵巢上皮性交界性肿瘤及58例上皮性卵巢癌中Skp2蛋白的表达情况。结果:Skp2在卵巢上皮性良性及交界性肿瘤中的表达均为阴性,而在上皮性卵巢癌中高表达,阳性率为48.28%(28/58),Skp2在中低分化组、Ⅲ/Ⅳ期组及有淋巴结转移组分别高于高分化组(P<0.01)、Ⅰ/Ⅱ期组(P<0.01)及无淋巴结转移组(P<0.01)。在不同年龄及组织类型的卵巢癌中表达无显著性差异。结论:Skp2在上皮性卵巢癌中表达,表达水平越高提示预后越差。Objective：To investigate expression of Skp2 protein in ovarian epithelial tumors and its clinical significance. Methods：Test ovarian epithelian tumor tissues of 83 cases with monoclonal antibody Skp2 by immunohistochemistry. Results： The rate of positive expression of Skp2 was 48. 28% in ovarian epithelial cancers. No expression of gene protein appeared in borderline and benign ovarian tumor tissues. Conclusion： Skp2 gene participate in origination and development of ovarian epithelial cancers, and higher expression of Skp2 indieats worse prognosis.

关 键 词：卵巢癌 SKP2 临床分期 病理分级 预后 

分 类 号：R737.31[医药卫生—肿瘤]