肺抑瘤合剂治疗肺癌及对小鼠Lewis肺癌cyclinD1表达影响的临床和实验研究  

Clinical and experimental study on the effects of treating lungcancer and the influence on the expression of cyclinD1 of lewis lung carcinoma in mice of Fei Yi Liu He Ji

作　　者：闫瑢玓[1] 郑翠娥[1] 

机构地区：[1]山东中医药大学附属第二医院职业病防治所,山东济南250011

出　　处：《世界急危重病医学杂志》2006年第3期1263-1263,共1页internationl journal of emergency and critical care medicine

摘　　要：【论文特点介绍】肺癌为当前世界各地最常见的恶性肿瘤之一，中医药治疗肿瘤是我国的特色和优势，通过辨证论治配合化疗等起到减毒增效、带瘤延年的良好效果。本研究为一个续贯课题，结合山东中医药大学附属医院呼吸内科多年的临床治疗肺癌的经验，根据中医基础理论，筛选出以益气养阴，清热解毒，化痰散瘀为主要治法的肺抑瘤合剂治疗中晚期肺癌。我们在临床观察治疗了78例肺癌患者，同时进行了肺抑瘤合剂对小鼠Lewis肺癌cyclinD1表达影响的实验研究，进一步探明了肺抑瘤合剂在肺癌综合治疗中发挥的作用机理。Objective The objectives of the present study are to evaluate the effectiveness of Fei Yi Liu He Ji in treating the lung cancer and to discuss its mechanism in treatment. Methods The study starts with 78 confirmed primary lung cancer patients who were randomly divided into two groups. 39 patients within the Treated Group were treated with Fei Yi Liu He Ji and chemotherapy together. The other 39 patients within the Controlled Group were treated with chemotherapy only. The clinical therapeutic effects were then observed. Lewis lung carcinoma model in mice was established; the carcinoma-inhibiting rate of Fei Yi Liu He Ji was examined; and the effects of Fei Yi Liu He Ji on the expression cyclinD1 in model mice were observed. Results in the clinical study, the Treated Group showed better than the Controlled Group in symptom betterment, improving the quality of existence, focus stabilization, lasting the time of existence, and weakening cancer and enhancing the effects of treatment. The experimental study suggests that Fei Yi Liu He Ji can obviously decrease the expression of cyclinD1 in the carcinoma cells and inhibit the growth of tumor. Conclusions The findings indicate that Fei Yi Liu He Ji is safe and effective in the combined-modality therapy of lung cancer, and that one of the Lewis lung carcinoma-inhibiting mechanism of Fei Yi Liu He Ji may be decreasing the expression of cyclinD1 in the carcinoma cells and halting the growth of the carcinoma cells in the G1 stage, and hence, making them be unable to develop into the S stage for DNA replication.

关 键 词：LEWIS肺癌 CYCLIND1 肺抑瘤合剂 中医药治疗 临床治疗 实验研 山东中医药大学附属医院 小鼠 中医基础理论 临床观察治疗 

分 类 号：R734.2[医药卫生—肿瘤] R735.2[医药卫生—临床医学]