Adaptation of a Biomineralization Strategy for Remineralization of Enamel and Dentin  

作　　者：梁志宏 陈治清 

机构地区：[1]Department of Dental Materials,West China College of Stomatology, Sichuan University,Chengdu 610041, China

出　　处：《Journal of Wuhan University of Technology(Materials Science)》2005年第B12期60-62,共3页武汉理工大学学报（材料科学英文版）

基　　金：FundedbytheNationalHighTechnologyResearchandDevelopmentProgramofChina(No.2002AA3260806)

摘　　要：The bio- inspired strategy of triggered release of Ca^2＋ , Pi, F from prosomal compartments was used to induce rapid formation of FHA for potential dental use ： Calcium and inorganic phosphate salts were separately loaded into temperature-sensitive liposome composed of 90% DPPC and 10% DMPC. When heated from the room temperature to 35- 37 ℃ , the entrapped calcium, inorganic phosphate and fl^rin released from the liposome,A mixture of Ca- Pi and F-loaded liposome formed apatite. The mineral was indicated by a rapid drop in suspension PH from 7.4 approximately 6. This was illustrated by applying a liposome suspension warmed human dentin and enamel surface which resulted in deposition of apatite onto the tissue substrates.The bio- inspired strategy of triggered release of Ca^2＋ , Pi, F from prosomal compartments was used to induce rapid formation of FHA for potential dental use ： Calcium and inorganic phosphate salts were separately loaded into temperature-sensitive liposome composed of 90% DPPC and 10% DMPC. When heated from the room temperature to 35- 37 ℃ , the entrapped calcium, inorganic phosphate and fl^rin released from the liposome,A mixture of Ca- Pi and F-loaded liposome formed apatite. The mineral was indicated by a rapid drop in suspension PH from 7.4 approximately 6. This was illustrated by applying a liposome suspension warmed human dentin and enamel surface which resulted in deposition of apatite onto the tissue substrates.

关 键 词：biomimetic bio-mineralization LIPOSOME matrix vesicle 

分 类 号：R318.08[医药卫生—生物医学工程]