人白细胞DR抗原基因与动脉粥样硬化性脑梗死关系的研究  

Research on association between atherosclerotic brain infarction and human leukocyte antigen DR gene

作　　者：张双彦[1] 邬英全[2] 于明[2] 曹峰林[1] 张宪忠[1] 

机构地区：[1]哈尔滨市第一医院,150010 [2]吉林大学中日联谊医院,130021

出　　处：《中国危重病急救医学》2006年第5期300-302,共3页Chinese Critical Care Medicine

基　　金：黑龙江省哈尔滨市青年科技基金项目(017421005)

摘　　要：目的探讨人白细胞DR抗原(HLA DR)基因与动脉粥样硬化性脑梗死(ABI)免疫遗传的相关性。方法采用聚合酶链反应和顺序特异性引物(PCR SSP)基因分析方法,对31例ABI患者及30名无血缘关系健康人的HLA DR部分等位基因及亚基因进行检测分析。结果ABI组HLA DR B1*0301等位基因相对危险度(RR)=5.6842,明显高于其他位点,差异有显著性(P<0.05);其他HLA DR B1*各等位基因未见异常。结论HLA DR B1*0301等位基因可能为北方汉族ABI患者的致病易感基因或与其他基因相连锁而共同致病。Objective To evaluate the relationship between atheroselerotic brain infarction （ABI） and human leukocyte antigen DR （HLA -DR） gene at molecular level. Methods By using polymerase chain reaction-sequence-specific probe （PCR -SSP）, gene special position of the HLA - Ⅱ DR alleles were determined in 31 patients and 30 healthy individuals as controls, all of them were inhabitants of Northeastern China. Results The HLA - DR B1^＊ 0301 gene frequency in the group of ABI was obviously higher than that of control group （RR = 5. 684 2, P〈0.05）. Conclusion The HLA- DR B1^＊ 0301 gene may be the susceptible gene of ABI in Northeastern China, or it may associate with other genes to produce the disease.

关 键 词：脑梗死 动脉粥样硬化 聚合酶链反应 顺序特异性引物 人白细胞DR抗原 基因多态性 易感基因 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R735.7[医药卫生—临床医学]