青蒿素及其衍生物抑制K562细胞生长作用比较  

Comparison on the growth inhibiting effects of three Artemisinine derivates on leukemia cell K562

作　　者：樊嵘[1] 谢红[1] 杨磊[1] 陈立军[1] 

机构地区：[1]武警医学院生化教研室,天津300162

出　　处：《武警医学院学报》2006年第3期199-201,共3页Acta Academiae Medicinae CPAPF

基　　金：天津市应用基础研究计划面上项目(05YFJMJC08200)

摘　　要：【目的】比较青蒿素、青蒿琥酯、双氢青蒿素对K562细胞生长的抑制作用。【方法】体外培养白血病K562细胞,3种药物作用于细胞,观察不同浓度的药物作用不同时间后,细胞数目的变化。【结果】3种药物在浓度为10-4、10-5、10-6mol/L时,细胞生长受到显著抑制,并呈剂量依赖性,且不同药物其抑制作用强弱有明显差异。【结论】青蒿素、双氢青蒿素及青蒿琥酯可以抑制肿瘤细胞K562的生长,且相同浓度下青蒿琥酯的作用最强。[Objective] To compare the growth inhibiting effects of 3 artemisinine dcrivates on leukemia cell K562. [Methods] K562 ceils were cultured. The cultured cells were treated by 3 artemisinine derivates with different concentrations and time. The growth of cells was observed by cell counting. [ Results] When the concentration of the 3 artemisininederivates was 10^-4, 10^-5, 10^-6 mol/L, the growth of cells was inhibited remarkably in dosage dependence. The growth inhibiting effect was different between 3 derivatcs at the same concentration. [ Conclusion] The three artemisinine derivates could inhibit the growth of tumor cells and the effect of artesunate was stronger than the other two at the same concentration.

关 键 词：青蒿素 双氢青蒿素 青蒿琥酯 白血病 生长抑制 

分 类 号：R361[医药卫生—病理学]