低剂量铅对神经细胞粘附分子表达的影响研究  

Study of the Impact of Low-level Lead on the Expression of Neural Cell Adhesion Molecule

作　　者：胡前胜[1] 任铁玲[1] 傅洪军[1] 董胜璋[1] 

机构地区：[1]中山大学公共卫生学院环境卫生学教研室,广州510080

出　　处：《科技导报》2006年第5期36-38,共3页Science & Technology Review

基　　金：国家自然科学基金项目(30271109;30371198);广东省科技计划项目(2004B33701005)

摘　　要：为了探讨神经细胞粘附分子(NCAM)在铅神经发育毒性中的作用,分别从体内、体外途径观察了低水平铅暴露对海马NCAM表达的影响。结果表明:铅明显抑制了海马神经元NCAM的表达,抑制程度随时间延长逐渐减弱,随剂量增加逐渐增强。提示:无论体内还是体外,低水平铅均显著抑制了Wistar大鼠海马NCAM的表达,并造成海马NCAM表达时程上的延迟。To explore the role of neural cell adhesion molecule （NCAM） on the lead neurotoxicity, the impact of lead on the expression of NCAM was studied with Wistar rats in vitro and in vivo respectively. Results showed that in vivo PbCl2 dose-responsively inhibited the expression of NCAM at 14 d, but till the 30 d, the pups＇ NCAM expression exceeded the control. The same trend of NCAM expression was observed in vitro. This study indicated that low-level lead significantly inhibited the expression of NCAM in Wistar rats＇ hippocampus especially at early development time and delayed it＇s expression phases.

关 键 词：铅 神经细胞粘附分子 海马 WISTAR大鼠 

分 类 号：R363[医药卫生—病理学]